Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: Report of six cases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34786412/
The rapid diagnosis of aGVHD is mainly based on the time from the first symptom, histopathological features, and the donor T-lymphocyte chimerism. Our cases report highlights massive corticosteroid therapy and...
Conclusion: The rapid diagnosis of aGVHD is mainly based on the time from the first symptom, histopathological features, and the donor T-lymphocyte chimerism. Our cases report highlights massive corticosteroid therapy and age difference between donors and recipients could accelerate to aGVHD. Moreover, gut microbial interventions and...
Mesenchymal Stromal Cells for the Treatment of Graft Versus Host Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34764962/
Graft versus host disease (GvHD) is a life-threating complication of allogeneic hematopoietic stem cell transplantation, which is initially treated with high dose corticosteroids. Approximately 50% of acute GvHD cases are...
It is well-established that extensive culture expansion of primary donor-derived MSCs leads to marked changes in functionality, and that there is a high level of inter-donor variability in MSC properties. However, recent manufacturing innovations may be capable of overcoming these problems. Further adequately powered prospective studies are...
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GvHD Connect4yrKey Points • Source: Frontiers in Immunology • Conclusion/Relevance: “The subject of this review is the use of mesenchymal stromal cells (MSCs) in the context of GvHD. Over the past two decades, Show More
Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34760617/
In the present study, we retrospectively analysed the results of HSCT in 47 consecutive patients with MDS diagnosed at our department between 2002 and 2019, with a focus on possible...
In a univariate analysis, the pre-transplantation value of blasts in the marrow 1000 ug/ml) nor increased C-reactive protein (CRP) (> 5 mg/l) was associated with shorter OS. In contrast, elevated serum lactate dehydrogenase (LDH) (> 213 U/l) was associated with shorter OS (p = 0.04).
The Oral Histopathological and Immunological Characteristics of a Xenogeneic Mouse Chronic Graft‐versus‐host Disease Model
Source : https://onlinelibrary.wiley.com/doi/10.1111/jop.13258
Qiaozhi Jiang , Xiangzhi Yong , Zhenmin Liu , Yuxi Zhou , Guocheng Mei , Qianming Chen , Tiantian Wu , Renchuan Tao , Corresponding Author Department of Periodontal and...
Inflammation in oral mucosa epithelium and salivary glands, and CD4 and CD8 T cells dominating infiltration are the main oral features in the xenogeneic cGVHD mouse model. The severity of oral histopathological lesions shows a dose and time correlation. These may be helpful to oral cGVHD research.
Letermovir Prophylaxis and Cytomegalovirus Reactivation in Adult Hematopoietic Cell Transplant Recipients with and without Acute Graft Versus Host Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34771734/
1 Comprehensive Cancer Center, James Cancer Hospital Solove Research Institute, The Ohio State University, 460 West 10th St., Columbus, OH 43210, USA. 2 Franciscan Health Indianapolis, 8111 South Emerson Avenue,...
This data suggests that letermovir prophylaxis improves outcomes by preventing CS-CMVi in patients with aGVHD.