Mesenchymal Stem Cells Enhance Chemotaxis of Activated T Cells through the CCL2-CCR2 Axis In Vitro - Bulletin of Experimental Biology and Medicine
Source : https://link.springer.com/article/10.1007/s10517-021-05373-3
Activation and migration of donor T cells to the host target organs are critical mechanisms in the pathogenesis of graft-versus-host disease (GVHD). The role of monocyte chemoattractant protein-1 (MCP-1/CCL2) and...
Conclusion/Relevance: Our results show that CCL2 levels in supernatants of co-cultures were significantly higher than in MSC monoculture and this increase depended on the number of MSC. MSC inhibited proliferation of T cells, but did not change the percentages of CD4 and CD8 T cells subsets. MSC can up-regulate the CCR2 expression in CD8 ...
Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34855460/
doi: 10.1200/JCO.21.02293. Online ahead of print. 1 Johns Hopkins Medical Center, Baltimore, MD. 2 Medical College of Wisconsin, Milwaukee, WI. 3 Dana Farber Cancer Institute, Boston, MA. 4 Emmes Company,...
Conclusion: CNI-free interventions as performed herein did not result in superior CRFS compared with tacrolimus and methotrexate with BM. Lower rates of moderate and severe cGVHD did not translate into improved survival.
Graft-Versus-Host Disease Prophylaxis with Post-Transplantation Cyclophosphamide versus Cyclosporine A and Methotrexate in Matched Sibling Donor Transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34856420/
1 Chaim Sheba Medical Center, Tel Hashomer, Israel and ALWP office Hôpital Saint-Antoine, Paris, France. 2 Department of Clinical Hematology and Cellular Therapy, Saint-Antoine Hospital, AP-HP, Sorbonne University, Paris, France;...
Conclusion/Relevance: In conclusion, GVHD prophylaxis with PTCy is feasible, resulting in similar incidences of GVHD, GRFS, LFS, and OS compared to conventional CSA/MTX in patients undergoing allo-HCT from MSD. The higher relapse observed with PTCy needs further evaluation in a prospective study.
Human leukocyte antigen (HLA) alleles as predictive factors for benefit from lenalidomide in acute myeloid leukemia (AML) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34824888/
1 HSCT Unit, Department of Medical Oncology Tata Memorial Centre, HSCT Unit, ACTREC Kharghar, Navi Mumbai 410210, Maharashtra, India. 2 Homi Bhabha National Institute (HBNI) Anushakti Nagar, Mumbai 410210, India....
Conclusion/Relevance: This is first study to show that HLA alleles may have a bearing on the effect of lenalidomide in AML and could serve as predictive biomarkers. These findings need to be confirmed in larger prospective studies.
Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34825089/
Hu-HSC NOG-Iab KO, HLA-DR 0405 Tg mice differed from conventional models in terms of B-cell activation and ANA production. This study is the first to report on B-cell activation and...
Conclusion/Relevance:u-HSC NOG-Iab KO, HLA-DR 0405 Tg mice differed from conventional models in terms of B-cell activation and ANA production. This study is the first to report on B-cell activation and autoantibody production in humanized mice with chronic GVHD, suggesting that hu-HSC NOG-Iab KO, HLA-DR 0405 Tg mice could be applied to a new...