Human leukocyte antigen (HLA) alleles as predictive factors for benefit from lenalidomide in acute myeloid leukemia (AML) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34824888/
1 HSCT Unit, Department of Medical Oncology Tata Memorial Centre, HSCT Unit, ACTREC Kharghar, Navi Mumbai 410210, Maharashtra, India. 2 Homi Bhabha National Institute (HBNI) Anushakti Nagar, Mumbai 410210, India....
Conclusion/Relevance: This is first study to show that HLA alleles may have a bearing on the effect of lenalidomide in AML and could serve as predictive biomarkers. These findings need to be confirmed in larger prospective studies.
Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34825089/
Hu-HSC NOG-Iab KO, HLA-DR 0405 Tg mice differed from conventional models in terms of B-cell activation and ANA production. This study is the first to report on B-cell activation and...
Conclusion/Relevance:u-HSC NOG-Iab KO, HLA-DR 0405 Tg mice differed from conventional models in terms of B-cell activation and ANA production. This study is the first to report on B-cell activation and autoantibody production in humanized mice with chronic GVHD, suggesting that hu-HSC NOG-Iab KO, HLA-DR 0405 Tg mice could be applied to a new...
High Levels of Donor‐derived Cell‐Free DNA in a Case of Graft‐Versus‐Host‐Disease Following Liver Transplantation
Source : https://onlinelibrary.wiley.com/doi/10.1111/ajt.16894
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between...
Conclusion/Relevance:Emerging noninvasive diagnostic techniques like the quantification of donor-derived cell-free DNA (dd-cfDNA) for surveillance may improve the current standard-of-care. Herein, we report the use of this methodology in a patient with GVHD and corresponding levels of dd-cfDNA without any evidence of graft injury. Correlation of...
IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34831324/
Mesenchymal stem cells (MSCs) are used in various studies to induce immunomodulatory effects in clinical conditions associated with immune dysregulation such as graft versus host disease (GvHD). However, most of...
Conclusion/Relevance: In summary, our studies demonstrate the feasibility of potentiating MSCs to enhance their immunomodulatory effects by IL-10 mRNA transfection. The use of non-viral transfection may generate a safe and potent MSC product for treatment of clinical conditions associated with immune dysregulation such as GvHD.
The impact of beta-blocker use at the time of hematopoietic cell transplantation on the development of acute and chronic graft-versus-host disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34780786/
Sympathetic nervous system activation plays a role in the development of acute and chronic graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (HCT). The primary objective was to compare the...
Conclusion: Results show a non-significant trend in the association between ß-blocker use and reduction in the risk of developing cGVHD (cause-specific hazard ratio 0.49, p = 0.060), with no negative impact on survival or relapse. The current data are supportive of a potential ß-adrenergic influence on the pathogenesis of GVHD, consistent with...