Updates in chronic graft-versus-host disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34889364/
Chronic graft-versus-host disease (GVHD) is the leading cause of late morbidity and mortality after allogeneic hematopoietic cell transplantation. Symptoms and manifestations of chronic GVHD are heterogeneous and pleomorphic, and there...
Conclusion/Relevance: Multi-institutional collaboration and pharmaceutical support in the development of therapies based on sound biologic mechanisms and clinical trials with defined end points and responses have led to several promising agents on the horizon of approval for treatment of chronic GVHD. This article reviews advances in our...
Histopathology of intestinal villi in neonatal and paediatric age: main features with clinical correlation - Part I | Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology
Source : https://www.pathologica.it/article/view/337
The neonatal and paediatric spectrum of small bowel disorders encompass a wide variety of conditions, ranging from food allergies to life-threatening surgical emergencies or lifelong medical conditions and, as such,...
Conclusion/Relevance: Specifically, in this first part, we describe congenital and metabolic disorders, intestinal lymphangiectasia, immunodeficiencies, GVHD, and necrotising enterocolitis.
Mesenchymal Stem Cells Enhance Chemotaxis of Activated T Cells through the CCL2-CCR2 Axis In Vitro - Bulletin of Experimental Biology and Medicine
Source : https://link.springer.com/article/10.1007/s10517-021-05373-3
Activation and migration of donor T cells to the host target organs are critical mechanisms in the pathogenesis of graft-versus-host disease (GVHD). The role of monocyte chemoattractant protein-1 (MCP-1/CCL2) and...
Conclusion/Relevance: Our results show that CCL2 levels in supernatants of co-cultures were significantly higher than in MSC monoculture and this increase depended on the number of MSC. MSC inhibited proliferation of T cells, but did not change the percentages of CD4 and CD8 T cells subsets. MSC can up-regulate the CCR2 expression in CD8 ...
Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34855460/
doi: 10.1200/JCO.21.02293. Online ahead of print. 1 Johns Hopkins Medical Center, Baltimore, MD. 2 Medical College of Wisconsin, Milwaukee, WI. 3 Dana Farber Cancer Institute, Boston, MA. 4 Emmes Company,...
Conclusion: CNI-free interventions as performed herein did not result in superior CRFS compared with tacrolimus and methotrexate with BM. Lower rates of moderate and severe cGVHD did not translate into improved survival.
Graft-Versus-Host Disease Prophylaxis with Post-Transplantation Cyclophosphamide versus Cyclosporine A and Methotrexate in Matched Sibling Donor Transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34856420/
1 Chaim Sheba Medical Center, Tel Hashomer, Israel and ALWP office Hôpital Saint-Antoine, Paris, France. 2 Department of Clinical Hematology and Cellular Therapy, Saint-Antoine Hospital, AP-HP, Sorbonne University, Paris, France;...
Conclusion/Relevance: In conclusion, GVHD prophylaxis with PTCy is feasible, resulting in similar incidences of GVHD, GRFS, LFS, and OS compared to conventional CSA/MTX in patients undergoing allo-HCT from MSD. The higher relapse observed with PTCy needs further evaluation in a prospective study.