Chronic graft-versus-host disease presenting as acute polymyositis: A case series and systematic review
Source : https://www.sciencedirect.com/science/article/abs/pii/S096632742100160X?via=ihub
Acute polymyositis is a rare manifestation of chronic graft vs host disease. * Usually presents with myalgia, proximal muscle weakness and high creatine kinase. * Biopsy shows perimysial inflammation and...
/>
Conclusion/Relevance: We present a case series of three patients who presented with APM as a sole presentation of cGvHD and were treated successfully with corticosteroids and ruxolitinib. We also conducted a systematic review including 72 patients to summarize current literature regarding APM associated with cGvHD after allo-HSCT.
Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis
Source : https://www.tandfonline.com/doi/full/10.1080/16078454.2021.2009645
ABSTRACT Myelofibrosis is a rare bone marrow disorder associated with a high symptom burden, poor prognosis, and shortened survival. While allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative...
Conclusion: Based on new data and clinical experience, the panel of experts discussed ruxolitinib treatment in Belgian myelofibrosis patients with a focus on dose optimization/monitoring, adverse events, and interruption/rechallenge management.
Cytokine autoantibodies are stable throughout the haematopoietic stem cell transplantation course and are associated with distinct biomarker and blood cell profiles - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34907183/
1 Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. [email protected]. 2 Department of Haematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 3 Department of Clinical Immunology, Rigshospitalet, University of...
Conclusion: In this first study of c-aAbs in HSCT patients, we demonstrated that high-titre levels of c-aAb may both persist and emerge in patients over the course of HSCT and may be associated with altered immune biomarkers and cell profiles.
Interleukin-2-inducible T-cell kinase (Itk) signaling regulates potent noncanonical regulatory T cells - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34919342/
Regulatory T cells (Tregs) play an important role in controlling autoimmunity and limiting tissue damage and inflammation. IL2-inducible T cell kinase (Itk) is part of the Tec family of tyrosine...
Conclusion: This peptide inhibitor also significantly reduced inflammatory cytokine production in primary GVHD patient samples and mouse T cells without causing cell death or apoptosis. We provide evidence that specifically targeting Itk signaling could be a therapeutic strategy to treat autoimmune disorders.
Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34880598/
1 Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, People's Republic of China. 2 Department of Hematology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine,...
Conclusion: Our real-world data from Chinese patients further confirm that ruxolitinib is a safe and effective treatment for SR-GVHD.