The combination of four main components in Xuebijing injection improved the preventive effects of Cyclosporin A in acute graft-versus-host disease mice by protecting intestinal microenvironment
Source : https://www.sciencedirect.com/science/article/pii/S0753332222000634?via=ihub
16S sequencing and transcriptomics were used to determine the protective mechanisms of C0127 in aGVHD mice. * C0127+CSA prevented intestinal microbiota disorders and gut damage. * XBJ/C0127+CSA reduced G-CSF-STAT3 axis...
Conclusion/Relevance: These findings indicated that C0127 improved the prevention of CSA in aGVHD mice partially by protecting the gut from damage through normalizing G-CSF signaling, which regulates the intestinal microbiota and the integrity of the epithelial barrier.
Day 4 vs. day 12 G-CSF administration following reduced intensity peripheral blood allogeneic stem cell transplant - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35191732/
Compared to day + 4, day + 12 G-CSF initiation following RIC alloHCT had a longer time to neutrophil and platelet engraftment. Day + 12 initiation also resulted in longer...
Conclusion: Compared to day 4, day 12 G-CSF initiation following RIC alloHCT had a longer time to neutrophil and platelet engraftment. Day 12 initiation also resulted in longer LOS, which while statistically significant, was potentially of limited clinical significance. These findings are hypothesis generating.
Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35180649/
1 Institute of Pathology, Germany. Electronic address: [email protected]. 2 Institute of Pathology, Germany. 3 3r Medical Department, Hematology, Oncology and Pneumology, Germany. 4 Institute of Neuropathology, Germany. 5 Institute of...
Relevance: We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regime, hepatic sinusoidal obstruction syndrome (hSOS), survival time, and graft versus host disease (GvHD).
Extracellular Vesicles as Biomarkers of Acute Graft-vs.-Host Disease After Haploidentical Stem Cell Transplantation and Post-Transplant Cyclophosphamide
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2021.816231/full
Even with high-dose post-transplant cyclophosphamide (PT-Cy) which was initially introduced for graft-versus-host disease (GvHD) prevention in the setting of HLA-haploidentical transplantation, both acute and chronic GvHDs remain a major clinical...
Conclusion/Relevance: This analysis showed that the combination of CD146, sTNFR1, and miR100 or miR194 strongly correlated with the onset of aGvHD (AUROC >0.975). A large prospective multicenter study is currently in progress to validate our findings.
Novel insights in CAR-NK cells beyond CAR-T cell technology; promising advantages - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35149294/
CAR-T (chimeric antigen receptor T cell) technology, which has recently showed successful results in the treatment of hematological tumors, has been the focus of attention as one of the most...
Conclusion/Relevance: In this narrative review, we outlined the key features of CAR-NK cells as an alternative to CAR-T cell therapy in cancer immunotherapy and highlighted the main advantages.