Highlighting the interaction between immunomodulatory properties of mesenchymal stem cells and signaling pathways contribute to Graft Versus Host Disease management
Source : https://www.sciencedirect.com/science/article/abs/pii/S0966327421001647?via=ihub
Allo-HSCT has been used as a therapeutic approach for hematological malignancies. * GVHD could significantly affect the morbidity and mortality of patients after allo-HSCT. * Mesenchymal stem cell (MSCs) mediated...
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Conclusion: MSCs could potentially modulate immune responses, prevent GVHD, and improve survival after allo-HSCT. Previous studies have investigated different signaling pathways' contributions to MSCs immunoregulatory ability. Accordingly, targeting signaling pathways components involved in MSCs related GVHD regulation is proven to be...
Hepatic venoocclusive disease/sinusoidal obstruction syndrome with normal portal vein flow mimicking aggravated chronic hepatic GVHD following inotuzumab ozogamicin salvage therapy: a case report of pathologic-radiologic discrepancy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34987745/
1 Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 2 Department of...
Relevance: Here, we describe a BCP-ALL patient treated with INO for isolated extramedullary relapse after allo-HCT.
Conclusion/Relevance: The transplant episode can be divided into a pre-transplantation assessment phase, an early post-transplantation phase (start of conditioning regimen to ∼3-6 months post-transplant), and a late post-transplantation phase (more than ∼3-6 months post-transplant).
Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34988692/
Although haploidentical donor lymphocyte infusion (DLI) is a valid treatment option for relapsed acute myeloid leukemia (AML), the incidence and risk factors for graft-versus-host disease (GVHD) and the efficacy of...
Conclusion/Relevance: Our results indicated the substantial risk of acute GVHD after haploidentical DLI with CD3 cell count of 5.0×105/kg or higher and the favorable outcomes after preemptive DLI.
HLA-DRB3/4/5 Matching Improves Outcome of Unrelated Hematopoietic Stem Cell Transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34970261/
The HLA-DRB3/4/5 loci are closely linked to the HLA-DRB1 gene. Mismatches in these loci occur with a frequency of about 8%-12% in otherwise 10/10 HLA-matched transplant pairs. There is preliminary...
Conclusion/Relevance: Our study results suggest that mismatches within the ARD of HLA-DRB3/4/5 genes significantly impact the outcome of otherwise fully matched uHSCT and support their consideration upon donor selection in the future.