Population Pharmacokinetics of Belantamab Mafodotin, a BCMA-targeting Agent in Patients with Relapsed/Refractory Multiple Myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34076364/
Belantamab mafodotin (belamaf) is an antibody-drug conjugate (ADC) targeting B-cell maturation antigen (BCMA). Nonlinear mixed-effects models were developed to characterize the population pharmacokinetics (PopPK) of ADC, total monoclonal antibody (mAb),...
Review of Venetoclax in CLL, AML and Multiple Myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34073976/
Venetoclax is a highly selective and effective B-cell lymphoma-2 (BCL-2) inhibitor, which is able to reinstate the apoptotic potential of cancer cells. With its full repertoire yet to be explored,...
KDM2A Targets PFKFB3 for Ubiquitylation to Inhibit the Proliferation and Angiogenesis of Multiple Myeloma Cells - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34079757/
The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis. However, many biological processes...
Health-related quality of life in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation: results from the randomized phase III ALCYONE trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34078314/
doi: 10.1186/s12885-021-08325-2. 1 Department of Haematology and Oncology, Würzburg University Medical Center, Oberdürrbacher Straße 6, 97080, Würzburg, Germany. [email protected]. 2 University Hospital of Salamanca-Instituto de Investigación Biomédica de Salamanca, Salamanca,...
Propensity-score matched analysis of the efficacy of maintenance/continuous therapy in newly diagnosed patients with multiple myeloma: a multicenter retrospective collaborative study of the Japanese Society of Myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34080068/
doi: 10.1007/s00432-021-03668-6. Online ahead of print. 1 Department of Hematology, Tokushima Prefectural Central Hospital, 1-10-3 Kuramoto, Tokushima, 770-8539, Japan. [email protected]. 2 Department of Hematology, Gunma University Graduate School of Medicine,...