M3258 is a selective inhibitor of the immunoproteasome subunit LMP7 (β5i) delivering efficacy in multiple myeloma models - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34045234/

2021 May 27;molcanther.MCT-21-0005-A.2021. doi: 10.1158/1535-7163.MCT-21-0005. Online ahead of print. 1 Translational Innovation Platform Oncology & Immuno-Oncology, Merck KGaA, Darmstadt, Germany [email protected]. 2 Merck KGaA. 3 Merck KGaA, Darmstadt, Germany. 4...

Validation of an Instrument for Measuring Adherence to Treatment With Immunomodulators in Patients With Multiple Myeloma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34045961/

doi: 10.3389/fphar.2021.651523. 1 Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 2 Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 3 Fundação Ezequiel Dias,...

Ocular Toxicity of Belantamab Mafodotin, an Oncological Perspective of Management in Relapsed and Refractory Multiple Myeloma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34046363/

Belantamab mafodotin (belamaf), an antibody-drug conjugate approved for the treatment of relapsed and refractory multiple myeloma (RRMM), is an anti B-cell maturation antigen (BCMA) agent. DREAMM-1, a first in-human trial...

Carfilzomib, dexamethasone and daratumumab in relapsed or refractory multiple myeloma: results of the phase III study CANDOR by prior lines of therapy

Source : https://onlinelibrary.wiley.com/doi/10.1111/bjh.17541

Bortezomib- and lenalidomide-based therapies have become standard front-line treatment for multiple myeloma (MM),1 resulting in many patients being refractory to bortezomib or lenalidomide at first relapse.2, 3 This may negatively...

Metabolic Changes Are Associated with Melphalan Resistance in Multiple Myeloma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34014671/

Multiple myeloma is an incurable hematological malignancy that impacts tens of thousands of people every year in the United States. Treatment for eligible patients involves induction, consolidation with stem cell...