Characteristics and Follow-Up of Organizing Pneumonia Associated with Haematological Malignancies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35027840/
This study demonstrates that haematological malignancies may be a cause of OP and that minimal invasive biopsy may be an effective and safe method to confirm the diagnosis. Although OP...
Conclusion: This study demonstrates that haematological malignancies may be a cause of OP and that minimal invasive biopsy may be an effective and safe method to confirm the diagnosis. Although OP associated with haematological malignancies may more frequently develop into severe cases, the OP lesions were steroid-responsive during follow-up.
SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34983615/
doi: 10.1186/s13046-021-02226-9. 1 Toni Stephenson Lymphoma Center, Beckman Research Institute of City of Hope, Duarte, CA, USA. [email protected]. 2 Judy and Bernard Briskin Center for Multiple Myeloma Research, Beckman Research...
Conclusion: Our study proves SUMOylation plays a crucial role in Dex resistance in MM and SUMOylation inhibition appears to be an attractive strategy to advance to the clinic for MM patients.
DOPA-Responsive Tremor Associated With Gammopathy: A Case Report and Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34984123/
Tremors have been well-described in association with monoclonal gammopathy. We report a case of a patient with asymmetric hands tremor who responded well to levodopa-carbidopa treatment. Further workup showed an...
Conclusion/Relevance: In this case, we are led to conclude that our patient's tremor was centrally mediated since it responded well to dopamine replacement therapy. However, further study is needed to elucidate the role of dopamine depletion in the pathogenesis of tremors associated with gammopathies.
Nutritional status alterations after chimeric antigen receptor T cell therapy in patients with hematological malignancies: a retrospective study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34988704/
The alterations of different nutrition-related biochemical parameters varied after CAR-T cell therapy. The levels of albumin and total cholesterol after CAR-T cell infusion were negatively correlated with the grade of...
Conclusion: The alterations of different nutrition-related biochemical parameters varied after CAR-T cell therapy. The levels of albumin and total cholesterol after CAR-T cell infusion were negatively correlated with the grade of cytokine release syndrome. Specific screening and intervention for malnutrition in patients receiving CAR-T cell...
The role of KIAA1191 in the necroptotic pathway of multiple myeloma - Annals of Hematology
Source : https://link.springer.com/article/10.1007/s00277-021-04710-w
Multiple myeloma (MM) is an incurable plasma cell malignancy, and International Staging System (ISS) is used to predict the outcomes of MM patients. However, ISS stage is imperfect, and there...
Conclusion/Relevance: We found that KIAA1191 was associated with both overall survival and progression-free survival of MM patients. Furthermore, KIAA1191 high expression suppressed the proliferation and migration of MM cells; upregulated the expression of RIP1, RIP3, and CYLD, and restored the TNF-α/z-VAD-induced necroptosis. Besides,...