Daratumumab for the Treatment of Multiple Myeloma: A Review of Clinical Applicability and Operational Considerations - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34963325/
doi: 10.1177/10600280211058754. Online ahead of print. 1 Specialty Pharmacy Service, Atrium Health, Charlotte, NC, USA. 2 Department of Pharmaceutical Services, Winship Cancer Institute, Emory University Hospitals, Atlanta, GA, USA. 3...
Conclusions: Daratumumab has led to a shift in the treatment paradigm of both newly diagnosed and relapsed/refractory MM, leading to improvements in outcomes such as response rates, depth of response, and progression-free survival.
Belantamab mafodotin for the treatment of multiple myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34821879/
Multiple myeloma is the second most common hematologic malignancy worldwide. Despite the growing number of available therapeutic options and advances in the treatment since the 2000s, relapse of multiple myeloma...
Conclusion/Relevance: Although belantamab mafodotin has demonstrated single-agent activity in relapsed/refractory multiple myeloma, further studies to evaluate its efficacy and its combinational use with other drugs are necessary and ongoing.
"Real-life" data of the efficacy and safety of belantamab mafodotin in relapsed multiple myeloma-the Mayo Clinic experience - Blood Cancer Journal
Source : https://www.nature.com/articles/s41408-021-00592-3
Belantamab mafodotin is a highly selective targeted therapy for multiple myeloma. It targets the B cell maturation antigen (BCMA) on plasma cells and showed promising results in several randomized clinical...
Conclusion/Relevance: In conclusion, the results of “real life” belantamab are similar to those published in the RCTs, and despite some promise, the role of belantamab in the era of other BCMA directed therapy (CAR-T, bispecific T cell engagers) remains unclear.
Clinical Usefulness of Transjugular Liver Biopsy in Patients With Hematological Diseases With Liver Dysfunction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34917436/
Introduction Transjugular liver biopsy (TJLB) is indicated for patients in whom percutaneous liver biopsy is contraindicated, such as those with hematological diseases complicated by liver dysfunction. However, the clinical utility...
Conclusion: The etiology of liver disorders in patients with hematological diseases varies widely. Therefore, histological diagnosis using TJLB is useful to determine an appropriate therapeutic strategy for underlying hematological diseases.
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Multiple Myeloma Connect4yrKey Points • Source: Cureus • Conclusion/Relevance: “The etiology of liver disorders in patients with hematological diseases varies widely. Therefore, histological diagnosis using TJLB [transjugular liver biopsy] is useful to determine an appropriate therapeutic Show More
The mRNA Expression and Regulation of Glucocorticoid Receptor Isoforms Associated with Response of Multiple Myeloma Treated with a Glucocorticoids-Dependent Regimen of Dexamethasone, Bortezomib and Thalidomide - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34921034/
Our findings raise the possibility that low expression of GRα and HSP90 plays important roles in nonresponders. Lack of HSP90 might affect GR structure and further take part in nonresponse....
Conclusion: Our findings raise the possibility that low expression of GRα and HSP90 plays important roles in nonresponders. Lack of HSP90 might affect GR structure and further take part in nonresponse. SRp30c and SRp40 mRNA expression both showed significant positive correlation with GRα. That might become new targets for treatment of...