The Role of Nucleophosmin 1 ( NPM1) Mutation in the Diagnosis and Management of Myeloid Neoplasms - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35054502/
Nucleophosmin (NPM1) is a multifunctional protein with both proliferative and growth-suppressive roles in the cell. In humans, NPM1 is involved in tumorigenesis via chromosomal translocations, deletions, or mutation. Acute myeloid...
Relevance: This review aims to summarize the role of NPM1 in normal cells and in human cancer and discusses its current role in clinical management of AML and related myeloid neoplasms.
Significance of WT1 and multiparameter flow cytometry assessment in patients with chronic myelomonocytic leukemia receiving allogeneic hematopoietic stem cell transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35061336/
doi: 10.1111/ijlh.13788. Online ahead of print. 1 Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell...
Conclusion: Both FCM and WT1 after HSCT were identified as important predictors of recurrence of CMML following transplantation and may be useful in guiding interventions against disease relapse.
A machine learning model based on tumor and immune biomarkers to predict undetectable MRD and survival outcomes in multiple myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35063966/
doi: 10.1158/1078-0432.CCR-21-3430. Online ahead of print. 1 Onco-hematology, Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA). 2 Molecular Biology-HLA, Departamento de Hematología, Hospital Universitario de Salamanca (HUSAL), IBSAL,...
Conclusion: It is possible to accurately predict MRD outcomes using an integrative, weighted model defined by machine learning algorithms. This is a new concept towards individualized treatment in MM.
Conditioning Intensity and Peri-Transplant Flow Cytometric MRD Dynamics in Adult AML - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34995355/
In acute myeloid leukemia (AML), measurable residual disease (MRD) before or after allogeneic hematopoietic cell transplantation (HCT) is an established, independent indicator of poor outcome. To address how peri-HCT MRD...
Conclusion/Relevance: Across conditioning intensities, peri-HCT MRD dynamics improve risk assessment over isolated pre- or post-HCT MRD assessments.
Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia
Source : https://bloodcancerdiscov.aacrjournals.org/content/3/1/66
We assessed minimal residual disease (MRD) detection and B-cell aplasia after tisagenlecleucel therapy for acute lymphoblastic leukemia (ALL) to define biomarkers predictive of relapse ( N = 143). Next-generation sequencing...
Relevance: Detectable disease by BMNGS-MRD with or without B-cell aplasia is highly predictive of relapse after tisagenlecleucel therapy for ALL. Clonotypic rearrangements used to follow NGS-MRD did not change after loss of CD19 or lineage switch. High-risk patients identified by these biomarkers may benefit from HCT or investigational cell...