Acute myeloid leukemia displaying clonal instability during treatment: implications for measurable residual disease assessments
Source : https://www.exphem.org/article/S0301-472X(22)00001-7/fulltext
Changes in the clonal composition of acute myeloid leukemia occur during therapy * Rare cases of outgrowth of clones related to non-malignant, but clonal hematopoiesis unrelated to the leukemic clone...
Conclusion: In conclusion, our results confirm the potential of refining MRD assessments by following multiple clones and warrants further studies into the precise interpretations of multi-clone NGS-MRD assays.
Haematopoietic Stem Cell Transplantation in Adolescents and Young Adults With Acute Lymphoblastic Leukaemia: Special Considerations and Challenges
Source : https://www.frontiersin.org/articles/10.3389/fped.2021.796426/full
Adolescents and young adults (AYAs) represent a challenging group of acute lymphoblastic leukaemia (ALL) patients with specific needs. While there is growing evidence from comparative studies that this age group...
Conclusion/Relevance: In this review, we summarise the key findings of recent studies on treatment approach and outcomes in this vulnerable patient group after HSCT, turning our attention to the different approaches applied in paediatric and adult centres. We focus on the specific needs of AYAs with ALL regarding social aspects and supportive...
Pitfalls in Assessing Measurable Residual Disease in Plasma Cell Myeloma: a Comparison between Common Laboratory Tests
Source : https://www.clin-lab-publications.com/article/3994
by Tariq N. Aladily, Ahmad T. Mansour, Feras Al-Fararjeh, Abdalla Awidi Background: Measurable residual disease (MRD) in plasma cell myeloma is one of the most important determinants for patients' outcome....
Conclusions: Both FC and IFE exhibited high sensitivity in detecting MRD in plasma cell myeloma with comparable results. IFE remains less invasive and less expensive than FC. Despite the lower sensitivity of bone marrow IHC staining, its diagnostic role is essential and can be superior to FC in a subset of cases, for which its routine...
Measurable residual disease in multiple myeloma and in acute myeloid leukemia, an evolving topic - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35076420/
Minimal or measurable residual disease (MRD) is a term that refers to the submicroscopic tumor disease persisting after therapy. Sensitive immunophenotypic and molecular techniques are used to detect the small...
Conclusion/Relevance: The finding that MRD evaluation may have a prognostic value, predicting the risk of relapse, stimulated interest in the introduction of MRD in clinical trials, either as a clinical endpoint or as a tool to guide treatment decisions. However, the clinical use of MRD requires a standardization of the techniques used for its...
Standard-Intensity Induction and Intermediate/High-Dose Cytarabine Consolidation Can Improve Survival for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia: A Retrospective Cohort Study
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786348/
There is great uncertainty in the treatment of elderly patients with acute myeloid leukemia (AML), which leads to great challenges in treatment decision. The aim of this study is to...
Conclusion: Our results showed that standard-intensity induction chemotherapy can significantly improve the CR rate for elderly AML patients, and does not increase the early mortality; consolidation therapy with intermediate or high-dose cytarabine can significantly improve EFS and OS for elderly AML patients achieved CR.