Single Centre Retrospective Analysis of Extracorporeal Photopheresis (ECP) Therapy in Patients Heavily Pre-Treated for Chronic Graft-Versus-Host Disease (cGvHD) With Steroid Failure
Source : https://www.sciencedirect.com/science/article/pii/S0145212623006525?via=ihub
Extracorporeal photopheresis (ECP) is recommended as a second- or later-line therapy for chronic GvHD (cGvHD). Benefits include reasonable response wi...
ECP is an effective treatment option for heavily pre-treated cGvHD patients.
We observed asymmetric di-methylation of IDH2 by PRMT1 at arginine 353 promoted IDH2 homodimerization, which enhanced IDH2 activity, further increasing B cell proliferation and antibody production. Collectively, this study provides a rationale for the application of PRMT1 inhibitors in the prevention of aGVHD and cGVHD.
Incidence and Outcome of Atypical Manifestations of Chronic Graft-Versus-Host Disease - Results From a Retrospective Single-Center Analysis
Source : https://www.sciencedirect.com/science/article/abs/pii/S2666636723015555?via=ihub
Chronic graft-versus-host disease (cGvHD) is the leading cause of late non-relapse mortality (NRM) after allogeneic stem cell transplantation (alloHSC...
In summary, atypical cGvHD is more common than previously estimated and has both, similarities with and differences from NIH-defined cGvHD. In particular, the increased NRM and a subset of patients with only atypical cGvHD point to the urgent need to capture these manifestations in cGvHD cohorts, including analysis of treatment outcome.
Sclerotic-type chronic graft-versus-host disease exhibits activation of Th1 and OX40 cytokines - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37742913/
Sclerotic-type cutaneous chronic graft-versus-host disease (ScGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation, with profound morbidity. A dearth of effective, targeted treatment options necessitates further investigation into...
Cell-type deconvolution revealed significant representation of macrophages and vascular endothelial cells. ScGvHD in young patients may therefore be characterized by strong Th1-related upregulation with a unique TSLP-OX40 signature, suggesting new therapeutic avenues for this devastating disease.
ER stress: an emerging regulator in GVHD development
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212215/full
Allogeneic hematopoietic cell transplantation (allo-HCT) is a promising therapeutic option for hematologic malignancies. However, the clinical benefits of allo-HCT are limited by the development of complications including graft-versus-host disease (GVHD)....
In this review, we summarize the current literature regarding the contribution of ER stress response to the development of GVHD in both hematopoietic and non-hematopoietic cells. Additionally, we explore the potential therapeutic implications of targeting UPR to enhance the effectiveness of allo-HCT for patients with hematopoietic...