Low incidence of hyperacute graft-versus-host disease (GVHD) with effective GVHD prophylaxis based on anti-thymocyte globulin - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35245388/
doi: 10.1111/bjh.18099. Online ahead of print. 1 APHP, Hôpital Saint Antoine, Service d'Hématologie Clinique et de Thérapie cellulaire, Paris, France. 2 Clinical Hematology and Bone Marrow Transplant Centre, S. Maria...
Conclusion: Overall, development of new strategies such as RTC and generalisation of in vivo T-cell depletion with ATG and/or PTCy, translate into a decreased incidence of haGVHD. Furthermore, despite a higher incidence of cGVHD in patients with haGVHD compared to aGVHD after day 14, NRM and OS were similar. This suggests that patients with...
Current status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35246235/
doi: 10.1186/s13287-022-02751-0. 1 Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, 130061, China. 2 National-Local Joint Engineering Laboratory of Animal...
Conclusion: In this study, we attempted to analyze the clinical trials for MSCs in GVHD, identify the most suitable group of patients for MSC therapy, and provide a new perspective for the design of such trials in the future.
The combination of four main components in Xuebijing injection improved the preventive effects of Cyclosporin A in acute graft-versus-host disease mice by protecting intestinal microenvironment
Source : https://www.sciencedirect.com/science/article/pii/S0753332222000634?via=ihub
16S sequencing and transcriptomics were used to determine the protective mechanisms of C0127 in aGVHD mice. * C0127+CSA prevented intestinal microbiota disorders and gut damage. * XBJ/C0127+CSA reduced G-CSF-STAT3 axis...
Conclusion/Relevance: These findings indicated that C0127 improved the prevention of CSA in aGVHD mice partially by protecting the gut from damage through normalizing G-CSF signaling, which regulates the intestinal microbiota and the integrity of the epithelial barrier.
Day 4 vs. day 12 G-CSF administration following reduced intensity peripheral blood allogeneic stem cell transplant - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35191732/
Compared to day + 4, day + 12 G-CSF initiation following RIC alloHCT had a longer time to neutrophil and platelet engraftment. Day + 12 initiation also resulted in longer...
Conclusion: Compared to day 4, day 12 G-CSF initiation following RIC alloHCT had a longer time to neutrophil and platelet engraftment. Day 12 initiation also resulted in longer LOS, which while statistically significant, was potentially of limited clinical significance. These findings are hypothesis generating.
Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35180649/
1 Institute of Pathology, Germany. Electronic address: [email protected]. 2 Institute of Pathology, Germany. 3 3r Medical Department, Hematology, Oncology and Pneumology, Germany. 4 Institute of Neuropathology, Germany. 5 Institute of...
Relevance: We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regime, hepatic sinusoidal obstruction syndrome (hSOS), survival time, and graft versus host disease (GvHD).