Identification of Targetable Gene Fusions and Structural Rearrangements to Foster Precision Medicine in KRAS Wild-Type Pancreatic Cancer

Source : https://ascopubs.org/doi/abs/10.1200/PO.20.00265

PURPOSE It has recently been described that alternative oncogenic drivers may be found in KRAS wild-type (KRASWT) pancreatic cancers. This study aimed to determine the incidence of targetable gene fusions...

BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors

Source : https://www.jci.org/articles/view/133090

The bromodomain and extra-terminal domain (BET) proteins are promising therapeutic targets to treat refractory solid tumors; however, inherent resistance remains a major challenge in the clinic. Recently, the emerging role...

Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia

Source : https://link.springer.com/article/10.1186/s13148-020-00979-2

Chronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic malignancy that arises from hematopoietic stem and progenitor cells (HSPCs). Patients with CMML are frequently treated with epigenetic therapeutic approaches, in particular...

Development of a nanotechnology-based approach for capturing and detecting nucleic acids by using flow cytometry

Source : https://doi.org/10.1016/j.talanta.2021.122092

Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target

Source : https://www.nature.com/articles/s41588-020-00758-y

Half of all colorectal cancers bear KRAS-activating mutations that affect the metabolic dependencies of cancer cells and drive resistance to commonly used drugs. A new study provides insights into KRAS-driven...