Conclusion/Relevance:In this study, we systematically investigated the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 gene editing. First, we confirmed and extended upon previous findings that selection13,14,15 of pre-existing p53 mutations by CRISPR-Cas9 can happen, showing it in a large set of transformed...

Conclusion/Relevance: Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, this type of mutation prevalence follows a population substructure pattern that can be...

Conclusion/Relevance: EGFR or ALK alterations occur in patients with LUSC, especially never-smoker females. TKI treatments render clinical benefit in disease control, but the duration was considerably truncated compared with those historically observed in LUAD.

Conclusions: c-MET immunohistochemistry was significantly higher in primary tumors with perineural invasion, female gender, and EGFR high expression. However, c-MET-high in the primary tumors was not significantly associated with longer survival compared with c-MET-low tumors. Further studies are required to investigate c-MET as potential...

Conclusion: Overall, our data suggest that cisplatin monotherapy may be more appropriate than pemetrexed monotherapy or combination therapy, as evidenced by the VEGFR-1 downregulation.