More Intensive Therapy Has a Better Effect for Frail Patients With Multiple Myeloma
VRd is superior to Rd in veterans with myeloma, and the evidence of benefit is strongest in those with the highest levels of frailty.
Net benefit of VRd over Rd in US veterans newly diagnosed with MM is strongest in patients with the highest levels of frailty, countering historical recommendations to consider doublets in this population.
Definers and Drivers of Functional High-Risk Multiple Myeloma: Insights From Genomic, Transcriptomic, and Immune Profiling
Source : https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1240966/full
Traditional prognostic models for newly diagnosed patients with multiple myeloma (MM), including International Staging System criteria and number of high-risk chromosomal abnormalities, are based on disease characteristics at diagnosis. However,...
In this review, we explore potential definitions of FHRMM before delving into its underlying drivers based on genetic, transcriptomic, and immune cell profiling studies. Emerging data suggest that specific features of both myeloma cells and immune cells can enable the FHRMM phenotype.
Immunomodulatory Properties of CD38 Antibodies and Their Effect on Anticancer Efficacy in Multiple Myeloma
Source : https://pubmed.ncbi.nlm.nih.gov/37840445/
Resistance mechanisms that undermine the immunomodulatory effects of CD38-targeting therapies can be tumor intrinsic, such as the downregulation of CD38 surface expression and expression of complement inhibitor proteins, and immune...
Resistance mechanisms to CD38 antibodies include tumor intrinsic mechanisms such as the downregulation of CD38 expression and alternative splicing of CD38 to prevent binding with antibodies, as well as immune microenvironment resistance mechanisms that include the change in NK-cell phenotype over the course of the disease.
Fifty Years of Unraveling the Clinical Pharmacology of Corticosteroids
Source : https://pubmed.ncbi.nlm.nih.gov/37844761/
This review will highlight portions of Dr. William Jusko's and colleagues' work that affected the clinical use and study of corticosteroids in acute and chronic disease management. Selected publications related...
Dr. Jusko's work opened the eyes of researchers and clinicians to the potential for disease and drug interactions that could reduce or enhance the effects of corticosteroids.
Molecular Genetic Aberrations in the Pathogenesis of Multiple Myeloma
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584387/
Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and...
NGS, which allows the analysis of the full spectrum of recurrent mutations and chromosomal abnormalities in MM, can become a powerful tool toward precision medicine in the treatment of MM. Importantly, NGS also enables rapid and accurate detection of clonal and subclonal mutations, which present at low variant allele frequencies in patients.