Bridging Treatment Prior to Chimeric Antigen Receptor T-Cell Therapy in Multiple Myeloma
Source : https://pubmed.ncbi.nlm.nih.gov/38036424/
Autologous patient-derived adoptive T-cell therapies have revolutionized the management of relapsed multiple myeloma (MM). However, the current manufacturing and quality control processes result in lengthy vein-to-vein time, making bridging therapy...
In this perspective piece, the authors provide their approach and considerations while selecting an optimal bridging regimen before autologous chimeric antigen receptor T-cell therapy.
Multi-Scale Geometric Network Analysis Identifies Melanoma Immunotherapy Response Gene Modules
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690163/
Melanoma response to immune-modulating therapy remains incompletely characterized at the molecular level. In this study, we assess melanoma immunotherapy response using a multi-scale network approach to identify gene modules with...
Using gene expression data of melanoma before and after treatment with nivolumab, researchers modeled gene expression changes in a correlation network and measured a key network geometric property, dynamic Ollivier-Ricci curvature, to distinguish critical edges within the network and reveal multiscale treatment-response gene communities.
Gene Interaction Network Analysis in Multiple Myeloma Detects Complex Immune Dysregulation Associated With Shorter Survival
Source : https://www.nature.com/articles/s41408-023-00935-2
The plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To investigate global interactions in MM, we combined a known protein interaction...
These results confirmed fidelity with known genomic risk factors as well as emerging factors not yet in clinical use.
Real-World Multiple Myeloma Risk Factors and Outcomes by Non-Hispanic Black/African American and Non-Hispanic White Race/Ethnicity in the United States
Source : https://haematologica.org/article/view/haematol.2023.282788
Examination of the impact of race and ethnicity on multiple myeloma (MM) outcomes has yielded inconsistent results. This retrospective, real-world (RW) study describes patient, disease, and treatment characteristics (and associations...
In general, associations between risk factors for rwPFS and rwOS were consistent between races/ethnicities.
Immunotherapy of Multiple Myeloma: Current Status as Prologue to the Future
Source : https://www.mdpi.com/1422-0067/24/21/15674
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic shift since the dawn of the current century. This has been driven largely by the introduction of...