Ki67 Proliferation Index in Germinal and Non-Germinal Subtypes of Diffuse Large B-Cell Lymphoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33728138/
Introduction Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma. The 2016 World Health Organization (WHO) update on hematopoietic tumors suggested that all DLBCL cases should be subtyped into...
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Mark Fesler4yrKi67 has long been a weak prognostic factor in dlbcl. This is the first I’ve seen of subtype specific ki67 information and the first association with myc IHC positivity Show More
CD19 CAR-T expressing PD-1/CD28 chimeric switch receptor as a salvage therapy for DLBCL patients treated with different CD19-directed CAR T-cell therapies
Source : https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01044-y
CD19-targeted chimeric antigen receptor T (CAR T) cell therapy is a promising option to treat relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). However, the majority of CAR T-treated patients will...
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Mark Fesler4yrThis work is somewhat preliminary but promising in that 50% of patients with a CaR enhancement achieved CR who failed prior standard CaR T ... will be interesting to continue Show More
ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma
Source : https://ascopubs.org/doi/full/10.1200/JCO.20.01366
PURPOSE Patients with the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) historically showed inferior survival with standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Phase II...
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Mark Fesler4yrA disappointing result in a disease subtype that needs better therapy One can still be hopeful for better targeted therapies as the molecular mechanisms of this hererogeneous disease Show More
Hypomagnesemia at the time of autologous stem cell transplantation for patients with diffuse large B-cell lymphoma is associated with an increased risk of failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33771971/
Magnesium is an essential element that is involved in critical metabolic pathways. A diet deficient in magnesium is associated with an increased risk of developing cancer. Few studies have reported...
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Mark Fesler4yrVery interesting study Low mg is probably largely related to platinum use in salvage treatment. Hard to reconcile why this might lead to worse lymphoma outcomes ....
Overlap between EBV‐positive diffuse large B‐cell lymphoma, NOS, in a young patient and angioimmunoblastic T‐cell lymphoma: A diagnostic pitfall
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981666/
There may be significant histopathologic overlap between EBV‐positive DLBCL, NOS, and other diagnoses including angioimmunoblastic T‐cell lymphoma (AITL). Resolution of this differential diagnosis may be particularly challenging and require extensive...
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Mark Fesler4yrI teach all of our fellows that any T cell lymphoma case should be seen by 2 different hematopathologists, with 1 being at an academic center where these cases are Show More