CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34413130/

Monotherapy with poly (ADP-ribose) polymerase (PARP) inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologous recombination (HR) DNA repair. New treatments are required for...

Detection of additional primary neoplasms on 18 F-Fluciclovine PET/CT in patients with primary prostate cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34413144/

Rationale: To evaluate the detection rate of incidental second primary neoplasms in patients with prostate cancer on 18F-Fluciclovine PET/CT. Methods: Imaging reports and patient demographic data were retrospectively reviewed from...

Analysis of human tissues using Energy Dispersive X Ray Fluorescence - Dark matrix determination for the application to cancer research

Source : https://www.sciencedirect.com/science/article/abs/pii/S0946672X21001279?via=ihub

X ray Fluorescence has been essayed as a suitable technique for the elemental quantification of trace element in human tissues, namely comparison of normal and cancerous tissue. However, accurate results...

Genetic testing for homologous recombination repair (HRR) in metastatic castration-resistant prostate cancer (mCRPC): challenges and solutions - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34381565/

Patients with metastatic castration-resistant prostate cancer (mCRPC) have an average survival of only 13 months. Identification of novel predictive and actionable biomarkers in the homologous recombination repair (HRR) pathway in...

Exosomes and prostate cancer management

Source : https://www.sciencedirect.com/science/article/abs/pii/S1044579X21002169?via=ihub

Exosomes (and other extracellular vesicles) are now part of the cancer research landscape, involved both as players in pathophysiological mechanisms, as biomarkers of the cancer process and as therapeutic tools....