Dose-Intensified Stereotactic Ablative Radiation for Localized Prostate Cancer
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899031/
Front Oncol. 2022; 12: 779182. Lily Chen, 1 Bhavani S. Gannavarapu, 2 Neil B. Desai, 2 Michael R. Folkert, 2 Michael Dohopolski, 2 Ang Gao, 3 Chul Ahn, 3 Jeffrey...
Conclusions: SAbR for PCa at 45 Gy in 5 fractions shows an encouraging safety profile. Prospective studies with longer follow-up are warranted to establish this dose regimen as standard of care for PCa.
Current standards and practice changing studies in genitourinary (GU) cancers-a review of studies in localized/early GU cancers - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35272133/
Optimizing treatment of genitourinary cancers in the early-stage setting continues to remain an area of need, given that the development of distant metastases is often the life-limiting factor in the...
Conclusion: In this article, we review the recently published studies in early-stage genitourinary cancers (renal cell, urothelial and prostate carcinomas), and their impact on disease outcomes and treatment practices. The results of subgroup analysis from some of these trials, with Asian patients enrolled, give assurance of the clinical...
Developing an immune-related gene prognostic index associated with progression and providing new insights into the tumor immune microenvironment of prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35271752/
We developed an immune-related gene prognostic index (IGPI) associated with progression and provided new insights into the tumor immune microenvironment (TIME) for prostate cancer (PCA) patients undergoing radical prostatectomy. All...
Conclusion: In conclusion, the IGPI score constructed in this study might serve as an independent risk factor associated with PCA progression. ADORA2A, CD80, TNFRSF4, TNFRSF18, and TNFRSF25 might be the potential targets in the treatment of PCA.
Application of Surface-Enhanced Raman Spectroscopy to Guide Therapy for Advanced Prostate Cancer Patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35271265/
doi: 10.1021/acssensors.1c02551. Online ahead of print. 1 Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. 2 Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 2G2....
Conclusions: Together, the presence and amount of AR-V7 in serum offer predictive and prognostic value to inform selection between two classes of systemic treatments (i.e., hormones or taxanes). Triaging patients that are AR-V7-positive to other systemic treatments (e.g., taxane-based chemotherapy) can improve progression-free survival and...
Neural-network dose-prediction for rectal spacer stratification in dose-escalated prostate radiotherapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35218024/
The feasibility of using a neural network to provide rapid decision support for RS insertion prior to RT has been demonstrated, and the potential for time and resource savings highlighted....
Conclusions: The feasibility of using a neural network to provide rapid decision support for RS insertion prior to RT has been demonstrated, and the potential for time and resource savings highlighted. Directly after target and healthy tissue delineation, the network is able to i) risk stratify most patients with a high degree of accuracy to...