Biomarkers for characterization and therapeutic orientation in castration-resistant prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35332889/
Article in English, Spanish] 1 Departamento de Urología. Hospital Universitario de Canarias. Tenerife. España. Grupo de Investigación en Neurociencia Clínica de la Universidad de La Laguna. España. 2 Departamento de...
Relevance: The aim is to review the current literature concerning prognostic and predictive marker of response to therapies in the mCRPC setting.
PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35333404/
CA is prevalent in PCa and arises predominantly by centriole overduplication as opposed to cell doubling events. Loss of centrioles is cellular stress that can promote senescence and suggests that...
Conclusions: CA is prevalent in PCa and arises predominantly by centriole overduplication as opposed to cell doubling events. Loss of centrioles is cellular stress that can promote senescence and suggests that PLK4 inhibition may be a viable therapeutic strategy in PCa.
Incidental prostate cancer after holmium laser enucleation of the prostate: incidence and predictive factors for clinical progression - International Journal of Clinical Oncology
Source : https://link.springer.com/article/10.1007/s10147-022-02156-2
Objectives To describe the incidental prostate cancer (iPCa) rate and identify predictive factors for PCa progression after holmium laser enucleation of the prostate (HoLEP). Methods A retrospective review of all...
Conclusion: In this study, post-operative PSA above 2 ng/mL was the only independent risk factor for iPCa progression after HoLEP. Patients with post-operative PSA ≥ 2 ng/mL must be considered to be at risk of progression and may require early curative treatment or closer follow-up in the post-operative period, especially when this is...
Calcium signaling in prostate cancer cells of increasing malignancy
Source : https://www.degruyter.com/document/doi/10.1515/bmc-2022-0012/html
Calcium signaling controls a large variety of cell functions, including proliferation and apoptosis, and plays a major role in neoplastic transformation. Prostate cancer (PCa) is one of the most common...
Conclusion/Relevance: Calcium signaling controls a large variety of cell functions, including proliferation and apoptosis, and plays a major role in neoplastic transformation. Prostate cancer (PCa) is one of the most common malignancies in men. The transition to castration-resistant prostate cancer (CRPC), a lethal form that is still lacking an...
Acceptance and efficacy of recommended adjuvant radiotherapy in patients with positive lymph nodes at radical prostatectomy: a preference-based study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35303155/
doi: 10.1007/s00345-022-03984-7. Online ahead of print. 1 Department of Urology, Zeisigwaldkliniken Bethanien Chemnitz, Im Verbund von AGAPLESION, Zeisigwaldstrasse 101, 09130, Chemnitz, Germany. [email protected]. 2 Department of Urology, University Hospital "Carl...
Conclusion: Adjuvant radiotherapy decreased mortality in patients with positive lymph nodes at radical prostatectomy with further disease factors but not in patients with low-risk disease. Simultaneous androgen deprivation might increase efficacy. Multidisciplinary recommendations may possibly increase the use of adjuvant radiotherapy in this...