Prostate Cancer Connect
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The Swedish national guidelines on prostate cancer, part 1: early detection, diagnostics, staging, patient support and primary management of non-metastatic disease

The Swedish national guidelines on prostate cancer, part 1: early detection, diagnostics, staging, patient support and primary management of non-metastatic disease

Source : https://www.tandfonline.com/doi/full/10.1080/21681805.2022.2094462

Abstract There is now an unprecedented amount of evidence to consider when revising prostate cancer guidelines. We believe that there is a value in publishing summaries of national clinical guidelines...


Conclusions: The 2022 Swedish prostate cancer guidelines include several new recommendations and some that differ from the European guidelines.

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Prostate Cancer Treatment with Pencil Beam Proton Therapy Using Rectal Spacers sans Endorectal Balloons - PubMed

Prostate Cancer Treatment with Pencil Beam Proton Therapy Using Rectal Spacers sans Endorectal Balloons - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35774493/

doi: 10.14338/IJPT-21-00039. 1 Department of Radiation Medicine, Georgetown University Hospital, Washington, DC, USA. 2 Department of Urology, Georgetown University Hospital, Washington, DC, USA. 3 Department of Radiology, Georgetown University Hospital,...


Conclusion: Early clinical outcomes of patients treated with PBS–PBT using Monte Carlo–based planning, fiducial placement, and rectal spacers sans endorectal balloons demonstrate minimal treatment-related toxicity with good oncologic outcomes. Rectal spacer stabilization without the use of endorectal balloons is feasible for the use of...

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    Key Points • Source: International Journal of Particle Therapy • Relevance: “Early clinical outcomes of patients treated with PBS–PBT using Monte Carlo–based planning, fiducial placement, and rectal spacers sans endorectal balloons demonstrate minimal treatment-related Show More
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Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies

Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies

Source : https://ascopubs.org/doi/10.1200/PO.22.00195

PURPOSE To study the impact of standard-of-care hormonal therapies on metastatic prostate cancer (mPC) clinical genomic profiles in real-world practice, with a focus on homologous recombination-repair (HRR) genes. PATIENTS AND...


Conclusion: Prevalence of HRR-gene aberrations remains stable along mPC progression, supporting the use of diagnostic biopsies to guide poly (ADP-ribose) polymerase inhibitor treatment in metastatic castration-resistant prostate cancer. gLOH scores increase with emerging resistance to hormonal therapies, independently of individual HRR gene...

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Editorial Comment on Ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer - PubMed

Editorial Comment on Ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35795116/

Nobumichi Tanaka is affiliated with an endowed chair funded by Nihon Medi‐Physics Co. Mariados N, Sylvester J, Shah D et al. Hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric...


Conclusion: Gathering and analyzing information concerning clinical experiences of hydrogel spacer can make a suitable indication and contra-indication criteria. Also, this effort must be necessary to achieve a safety use of hydrogel spacer and avoid severe adverse events in future.

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Ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer - PubMed

Ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35795104/

1 Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Ishikawa Japan. 2 Departments of Radiology Kanazawa University Graduate School of Medical Science Kanazawa...


Conclusions: Herein, we report the first case of ischemic proctitis after low-dose-rate brachytherapy using hydrogel spacer for prostate cancer.