Automatic radiotherapy delineation quality assurance on prostate MRI with deep learning in a multicentre clinical trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34507305/
Volume delineation quality assurance (QA) is particularly important in clinical trial settings where consistent protocol implementation is required, as outcomes will affect future as well current patients. Currently, where feasible,...
Conclusion/Relevance: To the best of our knowledge, this is the first study to propose automated delineation QA for a multicentre radiotherapy clinical trial with treatment planning MRI. The methods proposed in this work can potentially improve the accuracy and consistency of CTV and OAR delineation in radiotherapy treatment planning.
Late-Term Findings of Pancreatitis on 68Ga-PSMA PET/CT in a Patient With Prostate Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36026591/
The 68Ga-PSMA PET/CT imaging modality is used to evaluate biochemical recurrence, response to treatment, and staging in prostate cancer. Prostate-specific membrane antigen (PSMA) receptor activation can be seen in benign...
Relevance: The 68Ga-PSMA PET/CT imaging modality is used to evaluate biochemical recurrence, response to treatment, and staging in prostate cancer. Prostate-specific membrane antigen (PSMA) receptor activation can be seen in benign and malignant diseases as well as in many physiological tissues.
Targeted non AR mediated smart delivery of abiraterone to the prostate cancer
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272396
Prostate cancer is the second-deadliest tumor in men all over the world. Different types of drugs with various delivery systems and pathways were developed, but no one showed prominent results...
Relevance: Prostate cancer is the second-deadliest tumor in men all over the world. Different types of drugs with various delivery systems and pathways were developed, but no one showed prominent results against cancer. Meanwhile, nanoparticles have shown good results against cancer. Therefore, in the given study, citrate mediated synthesized...
Trends in Use of Granulocyte Colony-Stimulating Factor Following Introduction of Biosimilars Among Adults With Cancer and Commercial or Medicare Insurance From 2014 to 2019 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34812849/
1 Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville. 2 Center for Drug Evaluation and Safety, University of Florida, Gainesville. 3 College of Medicine, University...
Conclusions and Relevance: This cross-sectional study found that utilization of G-CSFs increased among patients with cancer with high FN risk in both a commercially and Medicare-insured population, but 14% to 17% of patients still did not receive preventive treatment.
High Dose "HDR-Like" Prostate SBRT: PSA 10-Year Results From a Mature, Multi-Institutional Clinical Trial
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.935310/full
Purpose/Objective(s)Although ample intermediate-term prostate stereotactic body radiotherapy (SBRT) outcomes have been reported, 10-year results remain relatively sparse.Materials/MethodsEighteen institutions enrolled 259 low- and intermediate-risk patients. Median follow-up is 5.5 years, with...
Conclusion: This HDR-like SBRT regimen prescribing 38 Gy/4 fractions but delivering much higher intraprostatic doses on a daily basis is safe and effective. This treatment achieves a median PSA nadir of