Development and Evaluation of 99mTc Tricarbonyl Complexes Derived from Flutamide with Affinity for Androgen Receptor - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36677878/
With the objective to develop a potential 99m Tc radiopharmaceutical for imaging the androgen receptor (AR) in prostate cancer, four ligands bearing the same pharmacophore derived from the AR antagonist...
Conclusions: The syntheses of four flutamide derivatives bearing different chelating units for coordinating 99mTc through the formation of tricarbonyl complexes were successfully achieved with high purity and adequate yield. The technetium complexes were also obtained with high radiochemical purity after HPLC purification, and their structures...
Targeted Radiation and Immune Therapies-Advances and Opportunities for the Treatment of Prostate Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36678880/
Prostate cancer is the most diagnosed malignancy in men in the United States and the second leading cause of cancer-related death. For localized disease, radiation therapy is a standard treatment...
Conclusions: This review provides an overview of the recent advances of targeted radiation agents currently approved for prostate cancer, and those being investigated in combination with immunotherapy, and discusses the challenges as well as the opportunities in this field.
Applications of artificial intelligence in prostate cancer histopathology
Source : https://www.sciencedirect.com/science/article/abs/pii/S1078143922004872?via=ihub
The diagnosis of prostate cancer (PCa) depends on the evaluation of core needle biopsies by trained pathologists. Artificial intelligence (AI) derived...
Conclusions: Artificial intelligence is evolving to diagnose, grade, and predict outcomes.
Single-cell RNA-Seq identifies factors necessary for the regenerative phenotype of prostate luminal epithelial progenitors
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831919/
Benign prostate hyperplasia and prostate cancer are common diseases that involve the overgrowth of prostatic tissue. Although their pathologies and symptoms differ, both diseases show aberrant activation of prostate progenitor...
Conclusions: We used single-cell (sc) RNA-Seq analysis to confirm the identity of a luminal progenitor cell population in both the hormonally intact and castrated mouse prostate. Using marker genes from our scRNA-Seq analysis, we identified factors necessary for the regeneration phenotype of prostate organoids derived from mice and humans in...
Tracking prostate cancer dynamics
Treatments targeting the androgen receptor have extended the lives of people with advanced prostate cancer. At first, prostate cancers need androgens like testosterone to survive, and blocking these hormones sends...
Conclusions: Single-cell study brings prostate tumors into focus and highlights potential treatment target: cancer complexity.