A randomized comparison of group mindfulness and group cognitive behavioral therapy vs control for couples after prostate cancer with sexual dysfunction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36763954/
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Conclusions: This is the first randomized clinical trial to test and demonstrate benefits among PCa survivors and partners’ sexual outcomes after CBT and mindfulness as compared with a nontreatment control group.
Natural history of incidentally diagnosed prostate cancer after holmium laser enucleation of the prostate
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0278931
Objectives There is no consensus on the management plan for incidental prostate cancer (IPCa) after holmium laser enucleation of the prostate (HoLEP). This study aims to investigate the natural course...
Conclusions: The incidence of IPCa after HoLEP was 5.4%, and among these, approximately 20% proceeded with immediate definitive therapy and an additional 6% ultimately received definitive therapy within a median of 4 years of AS but showed excellent oncological outcomes.
A systematic review and meta-analysis on overall survival,... : Anti-Cancer Drugs
ario. Methods Randomized clinical trials (RCT) were identified after systematic searching of databases. A random-effect model was used to determine the pooled hazard ratio (HR) for overall survival (OS) and...
Conclusions: The addition of either abiraterone, apalutamide, darolutamide or enzalutamide to ADT improves OS and failure-free survival in hormone-sensitive metastatic prostate cancer, albeit an increase in AEs.
A Multicompartmental Diffusion Model for Improved Assessment of Whole-Body Diffusion-weighted Imaging Data and Evaluation of Prostate Cancer Bone Metastases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36705559/
Purpose To develop a multicompartmental signal model for whole-body diffusion-weighted imaging (DWI) and apply it to study the diffusion properties of normal tissue and metastatic prostate cancer bone lesions in...
Conclusions: An optimized RSI model may provide a more comprehensive characterization of whole-body diffusion than conventional DWI methods. Higher lesion signal intensity on RSI signal-contribution maps may help to discriminate between cancerous and normal bone during whole-body cancer assessment, although formal clinical efficacy of RSI was...
KEYNOTE-991: pembrolizumab plus enzalutamide and androgen deprivation for metastatic hormone-sensitive prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36705526/
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Conclusions: The phase III randomized, placebo-controlled, double-blind KEYNOTE-991 trial will investigate the efficacy and safety of pembrolizumab versus placebo in combination with enzalutamide when initiating ADT in participants with mHSPC naive to next-generation hormonal agents