General Session 2 features latest findings from DESTINY-Breast02/03, TRIO-US B-12 TALENT trials - SABCS Meeting News
Wednesday morning's General Session 2 featured findings from three trials looking at the use of the antibody drug conjugate (ADC) trastuzumab deruxtecan (T-DXd) in HER2-positive metastatic and HER-2-low, HR-positive early-stage...
Conclusions: Wednesday morning’s General Session 2 featured findings from three trials looking at the use of the antibody drug conjugate (ADC) trastuzumab deruxtecan (T-DXd) in HER2-positive metastatic and HER-2-low, HR-positive early-stage breast cancer.
CDK4/6 Inhibitors as Upfront Treatment in a Patient with Breast Cancer Presenting with a Clinical Critic Situation: A Case Report and Review of the Literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36547170/
CDK4/6 inhibitors have revolutionized the treatment algorithm of luminal metastatic breast cancer, becoming the recommended first-line therapy in association with endocrine therapy. However, due to its theoretically greater and more...
Conclusions: The patient was treated with first-line Abemaciclib plus letrozole and achieved a rapid partial response with sudden clinical stabilization. Although the patient did not technically present with a visceral crisis, this case presentation also endorsed the upfront use of CDK4/6 inhibitor combinations in critical clinical situations in...
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Albert Dekker3yrvisceral crisis is relative term; furthermore, Ck4/6 are closer to chemotherapy than to traditional hormonal agents
CDK4/6 inhibitor resistance: A bibliometric analysis
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.917707/full
BackgroundCyclin-dependent kinases (CDKs) 4/6 inhibitors are a type of cell cycle regulation that prevents cell proliferation by blocking retinoblastoma protein (Rb) phosphorylation in the G1 to S phase transition. CDK...
Conclusions: This study provides researchers with a reliable basis and guidance for finding authoritative references, understanding research trends, and mining research neglect directions.
Trastuzumab deruxtecan (TDXd) in the second line for metastatic HER2 positive breast cancer shows improved overall survival over T-DM1 continued PFS benefit after longer follow up. This abstract was also presented at SABCS 2022.
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Sarah Mougalian, Yale Cancer Center3yrThose who relapsed >1 year after treatment would not have been eligible for this trial unless they had already received first line treatment with a taxane and trastuzumab. I think Show More -
Albert Dekker3yrthat is 100% true but I am concerned about very high percentage of patients who relapsed less then 6 months after completion of adjuvant therapy. I would currently consider Enhertu Show More
Exploring different computational approaches for effective diagnosis of breast cancer
Source : https://www.sciencedirect.com/science/article/abs/pii/S0079610722001201?via=ihub
Breast cancer has been identified as one among the top causes of female death worldwide. According to recent research, earlier detection plays an impo...
Conclusions: Simulation gives a road map for future discussions about developing improved early detection approaches that holds greater potential in increasing the survival rate of cancer patients. The different computational techniques can be a new dominion among researchers and combating the challenges associated with breast cancer.