Breast Cancer Connect
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Conclusions: Wednesday morning’s General Session 2 featured findings from three trials looking at the use of the antibody drug conjugate (ADC) trastuzumab deruxtecan (T-DXd) in HER2-positive metastatic and HER-2-low, HR-positive early-stage breast cancer.

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CDK4/6 Inhibitors as Upfront Treatment in a Patient with Breast Cancer Presenting with a Clinical Critic Situation: A Case Report and Review of the Literature - PubMed

CDK4/6 Inhibitors as Upfront Treatment in a Patient with Breast Cancer Presenting with a Clinical Critic Situation: A Case Report and Review of the Literature - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36547170/

CDK4/6 inhibitors have revolutionized the treatment algorithm of luminal metastatic breast cancer, becoming the recommended first-line therapy in association with endocrine therapy. However, due to its theoretically greater and more...


Conclusions: The patient was treated with first-line Abemaciclib plus letrozole and achieved a rapid partial response with sudden clinical stabilization. Although the patient did not technically present with a visceral crisis, this case presentation also endorsed the upfront use of CDK4/6 inhibitor combinations in critical clinical situations in...

  • 3yr
    visceral crisis is relative term; furthermore, Ck4/6 are closer to chemotherapy than to traditional hormonal agents
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CDK4/6 inhibitor resistance: A bibliometric analysis

CDK4/6 inhibitor resistance: A bibliometric analysis

Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.917707/full

BackgroundCyclin-dependent kinases (CDKs) 4/6 inhibitors are a type of cell cycle regulation that prevents cell proliferation by blocking retinoblastoma protein (Rb) phosphorylation in the G1 to S phase transition. CDK...

 

Conclusions: This study provides researchers with a reliable basis and guidance for finding authoritative references, understanding research trends, and mining research neglect directions.


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Trastuzumab deruxtecan (TDXd) in the second line for metastatic HER2 positive breast cancer shows improved overall survival over T-DM1 continued PFS benefit after longer follow up. This abstract was also presented at SABCS 2022.

  • 3yr
    Those who relapsed >1 year after treatment would not have been eligible for this trial unless they had already received first line treatment with a taxane and trastuzumab. I think Show More
  • 3yr
    that is 100% true but I am concerned about very high percentage of patients who relapsed less then 6 months after completion of adjuvant therapy. I would currently consider Enhertu Show More
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Exploring different computational approaches for effective diagnosis of breast cancer

Exploring different computational approaches for effective diagnosis of breast cancer

Source : https://www.sciencedirect.com/science/article/abs/pii/S0079610722001201?via=ihub

Breast cancer has been identified as one among the top causes of female death worldwide. According to recent research, earlier detection plays an impo...


Conclusions: Simulation gives a road map for future discussions about developing improved early detection approaches that holds greater potential in increasing the survival rate of cancer patients. The different computational techniques can be a new dominion among researchers and combating the challenges associated with breast cancer.