Biological Effects of Cyclin-Dependent Kinase Inhibitors Ribociclib, Palbociclib and Abemaciclib on Breast Cancer Bone Microenvironment - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35269621/
1 Department of Medical Oncology, Campus Bio-Medico University of Rome, 00128 Rome, Italy. 2 Royal Marsden Hospital NHS Trust, London SW3 6JJ, UK. 3 Department of Orthopedic and Trauma Surgery,...
Conclusion/Relevance: Overall, our results revealed the direct effects of CDKi on the tumor bone microenvironment, highlighting differences potentially relevant for clinical practice.
Influence of progesterone receptor on metastasis and prognosis in breast cancer patients with negative HER-2
Source : https://gs.amegroups.com/article/view/87989/html
The dramatic increase in breast cancer survival in recent years (since the 1970s) has been attributed to the discovery of hormone receptors (HRs), human epidermal factor growth receptor 2 (HER-2)...
Conclusions: ER−/PR subtype had a high proportion of stage IV patients. Meanwhile, such subtype breast cancer had similar clinicopathological characteristics, metastatic models (prefers to visceral metastasis), similar even worse prognosis compared with TNBC.
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Breast Cancer Connect4yrKey Points • Source: Gland Surgery • Conclusions: “ER−/PR+ subtype had a high proportion of stage IV patients. Meanwhile, such subtype breast cancer had similar clinicopathological characteristics, metastatic models (prefers to visceral metastasis), similar Show More
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Albert Dekker4yrI have not had many issues myself
Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination - European Radiology
Source : https://link.springer.com/article/10.1007/s00330-022-08655-0
Objectives To assess the frequency of ipsilateral axillary adenopathy on breast MRI after COVID-19 vaccination. To investigate the duration, outcomes, and associated variables of vaccine-related adenopathy. Methods In this retrospective...
Conclusions: Vaccine-related adenopathy is a frequent event after COVID-19 vaccination; short-term follow-up is an appropriate clinical approach, except in patients with current ipsilateral breast cancer. Adenopathy may often persist 4–8 weeks after the second dose of the vaccine, thus favoring longer follow-up periods.
Parkinson's disease and cancer: a systematic review and meta-analysis on the influence of lifestyle habits, genetic variants, and gender | Aging
Source : https://www.aging-us.com/article/203932/text
Purpose: The relationship between Parkinson's disease (PD) and cancer has been debated. Gender and genetic influences on cancer development in PD is unclear. Methods: Using QUOROM guidelines, we conducted a...
Conclusion: PD patients have reduced risks of colon, rectal, colorectal cancer and lung cancers and increased risks of brain cancer and melanoma. LRRK2-G2019S carriers have increased cancer risks, particularly brain, breast, colon and blood cancers. Female gender was associated with reduced risks. The role of ethnicity, comorbidities, and...
Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study
Source : https://www.frontiersin.org/articles/10.3389/fonc.2021.810023/full
BackgroundCyclin-dependent kinases (CDK) 4 and 6 regulate G1 to S cell cycle progression and are often altered in cancers. Abemaciclib is a selective inhibitor of CDK4 and CDK6 approved for...
Conclusions: Abemaciclib in combination with multiple endocrine therapy options exhibited manageable safety and promising antitumor activity in patients with HR , HER2- MBC.