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Relationship between ethnicity and stage at diagnosis in England: a national analysis of six cancer sites - PubMed

Relationship between ethnicity and stage at diagnosis in England: a national analysis of six cancer sites - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36702581/

Low symptom awareness and barriers to presentation can cause delays, resulting in later stage diagnosis. Targeted intervention campaigns to help raise awareness of cancer signs and symptoms and the benefits...



Conclusions: Low symptom awareness and barriers to presentation can cause delays, resulting in later stage diagnosis. Targeted intervention campaigns to help raise awareness of cancer signs and symptoms and the benefits of early diagnosis, along with removing barriers to appropriate referrals, could help to improve these inequalities.

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3yr
Genomic landscape of 891 RET fusions detected across diverse solid tumor types - npj Precision Oncology

Genomic landscape of 891 RET fusions detected across diverse solid tumor types - npj Precision Oncology

Source : https://www.nature.com/articles/s41698-023-00347-2

In this study, we report the clinicopathologic and genomic profiles of 891 patients with RET fusion driven advanced solid tumors. All patient samples were tested using a tissue-based DNA hybrid...


Conclusions: We present the clinicopathologic and genomic landscape of a large cohort of RET fusion positive tumors and we observed that liquid biopsy-based NGS is highly sensitive for RET fusions at cTF ≥1%.

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A Wrap-Up of the American Society of Clinical Oncology Gastrointestinal Cancers Symposium

The 2023 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium provided attendees with plenty of actionable tips for better managing patients with hard-to-treat gastric cancers. The three-day conference was held Jan. 19 to 21, 2023, at the Moscone West Building in San Francisco, with sessions also available online.

Click above to access a summary of highlights in our post-conference wrap-up.

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RET-MAP: An international multi-center study on clinicobiologic features and treatment response in patients with lung cancer harboring a RET fusion - PubMed

RET-MAP: An international multi-center study on clinicobiologic features and treatment response in patients with lung cancer harboring a RET fusion - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36646211/

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Conclusions: Patients with RET NSCLC have mainly thoracic and bone disease, and low TMB and PD-L1 expression. RETi significantly improve survival, while ICB may be active in selected patients.


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    Key Points • Source: Journal of Thoracic Oncology • Conclusion: “Patients with RET+ NSCLC have mainly thoracic and bone disease, and low TMB and PD-L1 expression. RETi significantly improve survival, while ICB may be Show More
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Original article: Central nervous system disease in patients with RET fusion-positive non-small cell lung cancer treated with selpercatinib - PubMed

Original article: Central nervous system disease in patients with RET fusion-positive non-small cell lung cancer treated with selpercatinib - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36657661/

CNS progression was not observed with selpercatinib therapy in patients without baseline CNS disease. CNS progression on selpercatinib was rare in patients with baseline CNS disease. Early initiation of selpercatinib...


Conclusions: CNS progression was not observed with selpercatinib therapy in patients without baseline CNS disease. CNS progression on selpercatinib was rare in patients with baseline CNS disease. Early initiation of selpercatinib is associated with decreased rates of CNS metastasis formation and progression, and may play a preventive role.