Pediatric thyroid surgery: Retrospective analysis on the first 25 pediatric thyroidectomies performed in a reference center for adult thyroid diseases
Source : https://www.frontiersin.org/articles/10.3389/fendo.2023.1126436/full
IntroductionPediatric thyroid carcinoma represents about 4-5% of all pediatric carcinoma with an incidence of 0.5 cases/100,000, compared to 2-10/100000 cases in the adult population. The aim of this study is...
Conclusions: Pediatric thyroid nodules are rare and distinguished from adult thyroid disease by a worse prognosis and higher malignancy rates. Our work reports a much higher malignancy rate among indeterminate TIR 3B lesions than observed in the adult population and the three patients who underwent prophylactic total thyroidectomy for...
Diffuse sclerosing variant papillary thyroid carcinoma has worse survival than classic papillary thyroid carcinoma: a meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36952650/
Diffuse sclerosing variant of papillary thyroid carcinoma (DSV) is a rare form of thyroid cancer that demonstrates more aggressive histopathology than classical papillary thyroid cancer (c-PTC) however if this leads...
Conclusions/Relevance: The high prevalence of RET fusions offers the potential to improve outcomes for patients with DSV.
A Familial Case of Multiple Endocrine Neoplasia 2A: From Morphology to Genetic Alterations Penetration in Three Generations of a Family - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36900098/
This paper illustrates a rare syndrome of multiple endocrine neoplasia type 2A (MEN2A) in a family of three generations. In our case, the father, son and one daughter developed phaeochromocytoma...
Conclusions/Relevance: A few lessons can be learned from this unique case. Successful diagnosis requires high suspicion and surveillance and a tri-level methodology including a careful review of family history, pathology and genetic counselling.
Challenges and strategies to combat resistance mechanisms in thyroid cancer therapeutics - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36924302/
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Conclusions: Progression-free survival is curtailed by developing acquired resistance. To minimise this therapeutic liability, clinicians must be anticipatory in identifying the drivers and characterising mechanisms of on target resistance.
The Changing Face of Multiple Endocrine Neoplasia 2A: From Symptom-Based to Preventative Medicine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36930525/
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Conclusion: These insights into MEN2A presentation, adjusted by birth year, illustrate the shift from reactive to preventative medicine, enabling less extensive risk-reducing surgery.