Exploring the Oral-Gut Microbiota During Thyroid Cancer: Factors Affecting the Thyroid Functions and Cancer Development
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563736/
Thyroid cancer (TC) is categorized into papillary, follicular, medullary, and anaplastic. The TC is increasing in several countries, including China, the United States, the United Kingdom, Canada, France, Australia, Germany,...
The variations in the composition of oral and gut microbes influence the thyroid function indirectly through alteration in metabolites (such as short-chain fatty acids) that are eminent for cellular energy metabolism. Maintenance of healthy gut and oral microbiota can help in regulating thyroid function by regulating iodine uptake. Oral or...
SAT535 ANKRD26-RET Fusion Positive Metastatic Papillary Thyroid Carcinoma - Advanced Presentation of a Rare Mutation
Source : https://academic.oup.com/jes/article/7/Supplement_1/bvad114.2006/7291165
Abstract. Disclosure: H. Hashmi: None. A. Ankireddypalli: None. L. Burmeister: None. A. Nelson: None. K. Amin: None.Background: While rearranged during transfec
The clinical and therapeutic implications of this rare genetic mutation are not currently well elucidated. We present this case with the intent to expand the existing literature and increase recognition of this rare genetic mutation.
Molecular Basis and Natural History of Medullary Thyroid Cancer: it Is (Almost) All in the RET
Source : https://www.mdpi.com/2072-6694/15/19/4865
Medullary thyroid cancer (MTC) is a rare disease, which can be either sporadic (roughly 75% of cases) or genetically determined (multiple endocrine neoplasia type 2, due to REarranged during Transfection...
Regarding MTC therapy, targeting RET with non-specific or specific tyrosine kinase inhibitors has produced promising results, leading to FDA approval for four molecules. Follow-up studies will allow us to determine whether new somatic mutations and alternative pathway activation might decrease the efficacy of these drugs on a long-term...
The Efficacy and Safety of Selective RET Inhibitors in RET Fusion-Positive Non-Small Cell Lung Cancer: a Meta-Analysis
Source : https://link.springer.com/article/10.1007/s10637-023-01390-3
Background Rearranged during transfection (RET) fusion-positive occurs in approximately 2% of non-small cell lung cancer (NSCLC). This mutation often predicts metastasis risk and poor prognosis, and current mainstream therapies provide...
Our results indicate that RET-TKIs have good efficacy and safety for RET fusion-positive NSCLC and intracranial metastases, and previously untreated patients have better drug responses than those who have received treatment.
Clinical Impact of Mixed Pulmonary Carcinoma and Carcinoid: the Driver From Their Mono-Clonal Origin
Source : https://link.springer.com/article/10.1007/s00428-023-03663-x
The combination of neuroendocrine/non neuroendocrine lung tumors (CNNELT) mentioned in the last edition of the World Health Organization (WHO) of Thoracic Tumors refers to small cell carcinoma (SCLC) or large...
Although it is a rare malignancy in the lung, mixed LUA and TC/AC could be included among the histotypes for which a deep molecular characterization of both components is needed to identify the presence of potential druggable genetic alterations.