Thirty Years of Progress Thanks to the RET Oncogene
Source : https://pubmed.ncbi.nlm.nih.gov/37870964/
Thirty Years of Progress Thanks to the RET Oncogene
Although medullary thyroid cancer accounts for less than 5% of thyroid cancers, it deserves attention because of its phenotypic heterogeneity, its often aggressive behavior, and the long-term lack of curative postoperative treatment.
Selpercatinib and Capmatinib Combination Promotes Sustained Complete Response in Novel ISOC1-RET Fusion Lung Cancer After Resistance to RET Inhibitor via MET Amplification: Case Report
Source : https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1264231/full
RET fusions occur in 1-2% of non-small cell lung cancer. Selpercatinib and pralsetinib are selective RET inhibitors with significant improvement of outcome in patients with tumor harboring RET fusion; however,...
To our knowledge, this is the first report of a novel ISOC1-RET fusion lung cancer with a durable complete response to selpercatinib, with resistance via MET amplification, which was overcome by the successful combination of selpercatinib and capmatinib.
Unleashing a Lazarus Effect With Selpercatinib in a Never-Smoker Patient With Stage IV, Chemo-Immunotherapy Refractory, RET C630Y-Mutant, Small-Cell Lung Cancer: a First Case Report
Source : https://pubmed.ncbi.nlm.nih.gov/37922409/
Unleashing a Lazarus Effect With Selpercatinib in a Never-Smoker Patient With Stage IV, Chemo-Immunotherapy Refractory, RET C630Y-Mutant, Small-Cell Lung Cancer: A First Case Report
A never-smoker, 52-year-old woman presented to the emergency room with seizures. Multiple brain metastases (>20 in number), located both supratentorially and infratentorially, including at least five exhibiting hemorrhage and intense edema, were confirmed by brain MRI. A right lower lobe (RLL) mass was visible on the chest radiograph, and...
This review underscores the pronounced variation in reported parameters within HSCR studies, highlighting the necessity for consistent, well-defined measures and reporting systems to foster improved data interpretability.
Pediatric Neuroendocrine Neoplasia of the Parathyroid Glands: Delving Into Primary Hyperparathyroidism
Source : https://www.mdpi.com/2227-9059/11/10/2810
Our objective was to overview the most recent data on primary hyperparathyroidism (PHP) in children and teenagers from a multidisciplinary perspective. Methods: narrative review based on full-length, English-language papers (from...
Individuals with an already-known genetic/familial condition are prone to asymptomatic PHP. The importance of preoperative imaging assessment was closely related to the usefulness of genetic testing before parathyroidectomy in providing information that influenced the surgical technique.