Infiltration of Gastric Cancer Stroma by Tumor-Infiltrating Lymphocytes Correlates with mTOR Signaling - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37315539/
mTOR possibly suppresses TIL infiltration in GC. H&E staining is an effective tool for evaluating the immune status of GC patients. H&E staining may be used in clinical practice to...
Conclusion: mTOR possibly suppresses TIL infiltration in GC. H&E staining is an effective tool for evaluating the immune status of GC patients. H&E staining may be used in clinical practice to monitor treatment response in GC.
Role of shrinkage in esophageal-gastric junction cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37312927/
The esophagus undergoes shrinkage after resection and fixation. The surgical in situ margin is greater than the specimen margin, measured by the pathologist. The length of disease-free margins is critical...
Conclusion: Tumor location and the resection margin are considered primary when determining the treatment for GOJ cancer. The length of disease-free margins is critical to postoperative therapeutic planning. We propose specimen fixing to avoid discrepancies between the operative finding and the pathological result. The oncological radicality,...
Prognostic Impact of Visceral Pleural Invasion in Resected Solitary Lung Metastases from Gastric Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37316253/
Pulmonary resection of solitary metastases from gastric cancer may be an effective therapeutic option to improve survival. VPI in gastric cancer metastasis is a negative prognostic factor.
Conclusion: Pulmonary resection of solitary metastases from gastric cancer may be an effective therapeutic option to improve survival. VPI in gastric cancer metastasis is a negative prognostic factor.
MST4 promotes proliferation, invasion, and metastasis of gastric cancer by enhancing autophagy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37313160/
High expression of MST4 indicates a poor prognosis and promotes GC cell proliferation, invasion, and metastasis by enhancing autophagy.
Conclusion: High expression of MST4 indicates a poor prognosis and promotes GC cell proliferation, invasion, and metastasis by enhancing autophagy.
MicroRNA-146a-5p induces cell cycle arrest and enhances apoptosis in gastric cancer via targeting CDC14A
Source : https://www.frontiersin.org/articles/10.3389/fcell.2023.1181628/full
Objective: The present study was designed to investigate the expression of miRNA-146a-5p in gastric cancer (GC) tissues and the paired nonmalignant counterparts, to explore the influences of miRNA-146a-5p on the...
Conclusion: The data suggest miRNA-146a-5p may contribute to inducing cell cycle arrest as well as prompting GC cell apoptosis via directly targeting CDC14A. Therefore, miRNA-146a-5p may be a potential indicator of the occurrence and development of GC.