Leptin stimulates migration and invasion and maintains cancer stem‑like properties in gastric cancer cells
Source : https://www.spandidos-publications.com/10.3892/or.2022.8377
Obesity is a risk factor for various types of cancer. Leptin, an adipocyte‑derived hormone, may stimulate the proliferation of gastric cancer cells. However, the effect of leptin and underlying mechanism...
Conclusion: The present findings support an adverse effect of obesity in gastric cancer. Consequently, targeting of leptin‑associated signaling pathways may have therapeutic potential for gastric cancer.
Pull the plug: Anti-angiogenesis potential of natural products in gastrointestinal cancer therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35871532/
Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common malignant tumor originating from the gastrointestinal epithelium. Although the pathogenesis of GIC has not been fully elucidated, angiogenesis...
Relevance: This review examines the anti-angiogenesis potential of natural products in the GIC treatment and provides clues to the development of vascular targeted agents.
The application of new gastric cancer screening score system for gastric cancer screening and risk assessment of gastric precancerous lesions in China - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35868004/
Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination...
Conclusions: The new gastric cancer screening score system is closely linked with histological OLGA/OLGIM staging system in the risk assessment of gastric precancerous lesions. The role of new gastric cancer screening score system in future gastric precancerous lesions screening and high risk population identifying was promising.
Health Care Utilization and Anti-Cancer Drug Expenditure for Six Solid Cancers in Korea From 2007 to 2019
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.862173/full
BackgroundThe burden of care continues to rise considerably worldwide and the challenge of diversity in cancer research has become important. We aimed to examine trends of cancer care utilization and...
Conclusion/Relevance: The anti-cancer drugs with the largest market shares were ramucirumab for gastric cancer; oxaliplatin for colorectal cancer; sorafenib for liver cancer; pembrolizumab, nivolumab, for lung cancer; trastuzumab for breast cancer; and bicalutamide for prostate cancer.
Ramucirumab in Indian Patients with Advanced Gastric Cancer-Does Borderline Performance Status and Heavy Burden of Disease in Real World Practice Impact Clinical Benefit?
Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1728980
Background Ramucirumab is considered a standard of care as second-line therapy (CT2) in advanced gastric cancers (AGCs). The aim of this study was to assess practice patterns and outcomes with ramucirumab...
Conclusions: Ramucirumab appears to have similar efficacy in Indian AGC patients when compared with real-world data from other countries in terms of median EFS, but OS appears inferior due to more patients having borderline ECOG PS and high metastatic disease burden. GI hemorrhages appear more common than published data, although not...