Renin‑angiotensin system inhibitors may have an advantage over calcium channel blockers in reducing proteinuria in gastric cancer patients receiving ramucirumab
Source : https://www.spandidos-publications.com/10.3892/br.2022.1559
This study aimed to investigate whether renin-angiotensin system inhibitors (RAS‑I) have an advantage over calcium channel blockers (CCB) for suppression of proteinuria in hypertensive patients with gastric cancer receiving ramucirumab...
Conclusion/Relevance: RAS-I may have an advantage over CCB for suppressing proteinuria in hypertensive patients with gastric cancer treated with blood pressure antihypertensive agents. Our results provide useful information to healthcare professionals involved in the administration of RAM treatment.
The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35877436/
The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of...
Conclusion: VEGF and CXCR4 play an important role in tumor progression. Their overexpression correlates with a bad prognosis and may improve high-risk patient selection, and these patients may obtain additional survival benefits if treated more aggressively.
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Gastric Cancer Connect4yrKey Points • Source: Current Issues in Molecular Biology • Conclusion: “The results of the presented research suggest a significant role of VEGF and CXCR4 in the biology of gastric cancer. The possible predictive Show More
68Ga-PSMA Uptake in Brain Metastasis of Gastric Carcinoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35930713/
A 69-year-old man with a known history of gastric and prostate adenocarcinoma was referred to 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging due to biochemical recurrence of prostate cancer. 68Ga-PSMA...
Relevance: This case reminds us of the variable spectrum of 68Ga-PSMA uptake in prostatic and nonprostatic metastatic lesions, the potential pitfalls on PET/CT images in the workup of patients with concomitant malignancies.
Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer
Source : https://www.hindawi.com/journals/cjgh/2022/5415758/
To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark...
Relevance: In this study, we outlined a novel stratification method including systematic pathway activity changes of gene sets in both tumor tissues and nontumor tissues and provided a more accurate prognostic model based on least absolute shrinkage and selection operator (LASSO) regression for patients with gastric cancer, which might help to...
Protocol of OGSG 1901: a phase II trial of ramucirumab plus irinotecan for patients with early relapsed gastric cancer during or after adjuvant docetaxel plus S − 1 therapy - BMC Cancer
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2
Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients...
Discussion: The results of this trial will indicate whether the ramucirumab with irinotecan regimen has the potential to be a recommended treatment regimen for patients with recurrence gastric cancer during or within 6 months after the completion of adjuvant docetaxel plus S-1 therapy.