Neoadjuvant and Adjuvant Therapy Approaches to Gastric Cancer - Current Treatment Options in Oncology
Source : https://link.springer.com/article/10.1007/s11864-022-01004-9
Gastric cancer is an aggressive malignancy, requiring a multimodality approach to achieve optimal curative rates even when the disease is amenable to surgical resection. Neoadjuvant and adjuvant approaches differ across...
Relevance: Gastric cancer is an aggressive malignancy, requiring a multimodality approach to achieve optimal curative rates even when the disease is amenable to surgical resection. Neoadjuvant and adjuvant approaches differ across the globe—a preference for peri-operative chemotherapy exists in Europe, in contrast to the adoption of adjuvant...
Early increase of plasma soluble VEGFR-2 is associated with clinical benefit from second-line treatment of paclitaxel and ramucirumab in advanced gastric cancer
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360220/
Gastric cancer (GC) is the fifth most frequently diagnosed tumour and the fourth leading cause of cancer-related death worldwide [ 1]. Metastatic GC is characterized by poor prognosis and systemic...
Relevance: Gastric cancer is an aggressive malignancy, requiring a multimodality approach to achieve optimal curative rates even when the disease is amenable to surgical resection. Neoadjuvant and adjuvant approaches differ across the globe—a preference for peri-operative chemotherapy exists in Europe, in contrast to the adoption of adjuvant...
Early gastric neoplasms are significant risk factor for colorectal adenoma: A prospective case-control study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35960053/
Although gastric cancer patients have a high incidence and risk of colorectal cancer, evidence is lacking regarding whether early gastric neoplasms (EGNs), such as gastric adenomas and early gastric cancer,...
Conclusion/Relevance: This is the first prospective study to reflect the quality indicator of colonoscopy and confirmed that old age and a history of EGN are significant risk factors for colorectal adenomas. Therefore, more stringent colonoscopy surveillance should be considered in elderly patients with EGN.
Circulating tumor DNA for diagnosis, prognosis and treatment of gastrointestinal malignancies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35949436/
Minimally invasive detection of circulating tumor DNA (ctDNA) in peripheral blood or other body fluids of patients with gastrointestinal malignancies via liquid biopsy has emerged as a promising biomarker. This...
Relevance: Minimally invasive detection of circulating tumor DNA (ctDNA) in peripheral blood or other body fluids of patients with gastrointestinal malignancies via liquid biopsy has emerged as a promising biomarker.
Ramucirumab in Indian Patients with Advanced Gastric Cancer-Does Borderline Performance Status and Heavy Burden of Disease in Real World Practice Impact Clinical Benefit? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35833042/
Vikas Ostwal Background Ramucirumab is considered a standard of care as second-line therapy (CT2) in advanced gastric cancers (AGCs). The aim of this study was to assess practice patterns and...
Conclusions: Ramucirumab appears to have similar efficacy in Indian AGC patients when compared with real-world data from other countries in terms of median EFS, but OS appears inferior due to more patients having borderline ECOG PS and high metastatic disease burden. GI hemorrhages appear more common than published data, although not...