Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, TP53, SMAD4 and a potential role of the PI3K-AKT and EGFR pathways: a case report
Source : https://jgo.amegroups.com/article/view/65385/html
Typically, early-onset gastric cancers (EOGC) present at the age of 45 years old or younger. Although its prevalence ranges from 2.7% to 15% depending on the population being studied, it...
Conclusions: As explained above EOGC is a growing health concern that affects young individuals. Furthermore, the reported case displayed a poor response to standard therapy including checkpoint inhibitors and chemotherapy despite the presence of biomarkers that predict a favorable outcome. Future studies should adopt alternative approaches to...
Differences in Pretreatment Frailty Across Gastrointestinal Cancers in Older Adults: Results From the Cancer and Aging Resilience Evaluation Registry
Source : https://ascopubs.org/doi/abs/10.1200/OP.22.00270
PURPOSE: Frailty predicts poor outcomes in older adults with cancer, but how it differs between different cancer types is unknown. We examined differences in pretreatment frailty between colorectal (CRC), pancreatic,...
Conclusion: Screening and intervention on FT for patients with hematologic malignancies is associated with increased quality of life and survival.
Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection
Source : https://www.hindawi.com/journals/jo/2022/7299360/
Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection: Endoscopic submucosal dissection (ESD) is a minimally invasive technique to...
Conclusion: Compared with simple intravenous general anesthesia, intravenous combined inhalation general anesthesia can better maintain the intraoperative hemodynamic stability of patients with early gastric cancer, shorten the postoperative recovery time, and reduce the postoperative pain. On the other hand, this study is a retrospective study,...
A predictive model for early death in elderly patients with gastric cancer: A population-based study
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.972639/full
BackgroundThe mean age of gastric cancer (GC) patients has increased due to the aging society. Elderly GC patients with poor physical status tend to develop complications during the treatment courses,...
Conclusions: These nomogram models were considered a practical tool to identify the early death of elderly GC patients and help provide a more individualized treatment strategy.
Gut Microbiota Dysbiosis in the Development and Progression of Gastric Cancer
Source : https://www.hindawi.com/journals/jo/2022/9971619/
Gut Microbiota Dysbiosis in the Development and Progression of Gastric Cancer: Objectives . This study aims to explore gut microbiota dysbiosis in the histological stages of gastric cancer (GC). Methods...
Conclusions: We identified differences in microbial compositional changes across stages of GC. Six genera and two metabolic pathways were more abundant in the GC group than noncancer groups, suggesting that these findings may contribute to the therapy strategies in GC in the near feature.