ERp44 Regulates the Proliferation, Migration, Invasion, and Apoptosis of Gastric Cancer Cells Via Activation of ER Stress - Biochemical Genetics
Source : https://link.springer.com/article/10.1007/s10528-022-10281-w
Gastric cancer (GC) is one of the most prevalent malignancies worldwide. Endoplasmic reticulum (ER) stress plays a key role in the progression of GC. Rapid proliferation of tumor cells interferes...
Conclusion: Taken together, our data demonstrated that ERp44 regulated the proliferation, migration, invasion, and apoptosis via ERp44/eIF-2α/CHOP axis in GC. Targeting the ERp44and ER stress may be a promising strategy for GC.
Galectin‑1 binds GRP78 to promote the proliferation and metastasis of gastric cancer
Source : https://www.spandidos-publications.com/10.3892/ijo.2022.5431
The present study aimed to investigate the potential molecular mechanisms by which galectin‑1 (Gal‑1) and glucose‑regulated protein 78 (GRP78) influence the development of malignant gastric cancer (GC). Immunohistochemistry and western...
Conclusion: Gal‑1 interacts with GRP78 to facilitate the advancement of GC. The Gal‑1/GRP78 axis is supported by the functional data of the present study as a possible GC treatment target.
The factors influencing the accuracy of pre-operative endoscopic ultrasonography assessment in endoscopic treatments for gastrointestinal tumors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36177606/
doi: 10.1002/cam4.5305. Online ahead of print. 1 Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. 2 Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University,...
Conclusions: Our findings suggested that EUS is a reliable and easy-to-use diagnostic tool in decision-making regarding appropriate endoscopic treatment for gastrointestinal tumors. However, the diagnostic accuracy of EUS appeared questionable in the presence of ulceration.
PTEN Expression Was Significantly Associated with PD-L1 Score but Not | OTT
Gastric cancer (GC) is a kind of worldwide malignancy, with the incidence rate ranked fifth and the mortality rate ranked third. Despite improvements in surgical and chemotherapeutic treatment, the overall...
Conclusion: The above results suggested that PTEN expression was a useful marker in gastric carcinogenesis and progression and in the selection of immunotherapy-based treatments for GC patients.
Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36149600/
In this review, we highlight recent clinical trial data reported in the literature dealing with different ways to target various carcinogens in gastric cancer. Moreover, we touch upon other multidisciplinary...
Conclusions: In this review, we highlight recent clinical trial data reported in the literature dealing with different ways to target various carcinogens in gastric cancer. Moreover, we touch upon other multidisciplinary therapeutic approaches such as surgery, adjuvant and neoadjuvant chemotherapy. Rational clinical trials focusing on...