The role of cancer-associated fibroblasts in tumorigenesis of gastric cancer - Cell Death & Disease
Source : https://www.nature.com/articles/s41419-022-05320-8
Despite advances in anticancer therapy, the prognosis of gastric cancer (GC) remains unsatisfactory. Research in recent years has shown that the malignant behavior of cancer is not only attributable to...
Relevance: As one of the main components in the tumor environment (TME), cancer-associated fibroblasts (CAFs) are extensively involved in the progression of malignant tumors, including GC.
Successes and failures of angiogenesis blockade in gastric and gastro-esophageal junction adenocarcinoma
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.993573/full
Gastric and gastro-esophageal junction adenocarcinoma (GEA) remains a considerable major public health problem worldwide, being the fifth most common cancer with a fatality-to-case ratio that stands still at 70%. Angiogenesis,...
Conclusion/Relevance: In this article, we critically review the existing literature on the biological rationale and clinical development of antiangiogenic agents in GEA, discussing major achievements, limitations and future developments, aiming at fully realizing the potential of this therapeutic approach.
Research progress in targeted therapies for gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36197788/
Patients with advanced gastric cancer experience rapid disease progression with limited survival, high mortality, and a lack of surgical options. Thus, radiochemotherapy or a combination of chemotherapeutics with targeted therapy...
Conclusion/Relevance: Currently, there are two major classes of molecularly targeted drug regimens that have achieved a certain efficacy in clinical practice: anti-vascular endothelial growth factor (anti-VEGF) therapy and anti-epidermal growth factor receptor (anti-EGFR) therapy. Trastuzumab has been approved as the standard of care for...
Estrogen-responsive cancer-associated fibroblasts promote invasive property of gastric cancer in a paracrine manner via CD147 production - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36197688/
Estrogen signaling has been extensively studied, especially in cancers that express estrogen receptor alpha (ERα). However, little is known regarding the effect of estrogen on cancer-associated fibroblasts (CAFs). Here, we...
Relevance: Our data suggest that estrogen signaling activation in CAFs and the byproduct CD147 are among the critical mediators between the interplay of CAFs and cancer cells to facilitate cancer progression.
Identification of ferroptosis-related genes for the prediction of prognosis and chemotherapy benefit of gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36196723/
Objective: As a newly reported programmed cell death, ferroptosis plays a crucial role in tumor progression. We aimed to comprehensively analyze the prognostic value of ferroptosis-related genes and identify the...
Conclusions: The developed ferroptosis gene-set based prognostic signature indicated superior prognostic and predictive value, suggesting new possibilities for individualized treatment of GC patients.