p16 methylation is a potential predictive marker for abemaciclib sensitivity in gastric cancer
Source : https://www.sciencedirect.com/science/article/abs/pii/S0006295220305566?via=ihub
Cell cycle control is often disrupted in gastric cancer (GC), making it an attractive therapeutic target. Abemaciclib is a specific CDK4/6 inhibitor that has been shown to improve treatment efficacy...
Relevance: Cell cycle control is often disrupted in gastric cancer (GC), making it an attractive therapeutic target. Abemaciclib is a specific CDK4/6 inhibitor that has been shown to improve treatment efficacy in hormone receptor-positive advanced breast cancer; however, its potential therapeutic value and predictive markers have not yet been...
Establishment and characterization of adult human gastric epithelial progenitor-like cell lines - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36331058/
Our culture system of hGEPL cells from adults is robust and easy to operate, and has the transformative potential of personalized and precision medicine, laying a solid foundation for studying...
Conclusions: Our culture system of hGEPL cells from adults is robust and easy to operate, and has the transformative potential of personalized and precision medicine, laying a solid foundation for studying the self-renewal and differentiation potentials of gastric epithelial stem/progenitor cells as well as modelling of related gastric diseases.
Successful outcome of neoadjuvant PD-1 blockade, VEGFR-2 inhibitor plus chemotherapy for potentially unresectable esophagogastric junctional squamous cell carcinoma: a case report
Source : https://tcr.amegroups.com/article/view/66878/html
Gastric squamous cell carcinoma (SCC) is a rare malignancy, its incidence is less than 2% among all gastric cancers, and esophagogastric junctional SCC (EJSCC) occupies over 80% ( 1). The...
Conclusions: PD-1 blockade, VEGFR-2 inhibitor plus chemotherapy is effective and safe for the patient with EJSCC.
Health Benefits and Pharmacological Properties of Stigmasterol - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36290632/
Stigmasterol is an unsaturated phytosterol belonging to the class of tetracyclic triterpenes. It is one of the most common plant sterols, found in a variety of natural sources, including vegetable...
Conclusions: This review outlines key insights into the pharmacological abilities of stigmasterol and the specific mechanisms of action underlying some of these effects. Additionally, further investigation regarding pharmacodynamics, pharmacokinetics, and toxicology is recommended.
Targeting FGFR2 positive gastroesophageal cancer | OTT
Gastroesophageal cancer encompasses three major subdivisions which are histologically, epidemiologically, and pathologically different: gastric adenocarcinoma, gastroesophageal junctional (GEJ) adenocarcinoma and oesophageal cancer, which is further classified into squamous cell carcinoma...
Relevance: In our review, we outline the FGFR pathway and focus on the developments and challenges of targeting FGFR2 driven gastroesophageal cancers.