Treatment efficacy of ramucirumab-containing chemotherapy in patients with alpha-fetoprotein producing gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36409433/
doi: 10.1007/s10147-022-02263-0. Online ahead of print. 1 Department of Gastrointestinal Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake Koto-ku, Tokyo, 135-8550, Japan. 2 Department of Gastrointestinal...
Conclusions: "Conclusion: Ramucirumab containing chemotherapy showed higher response and comparable survival in AFPGC compared to those of non-AFPGC. Considering the generally poor prognosis of AFPGC, ramucirumab-containing chemotherapy might be a promising treatment option in AFPGC."
Time-to-event surrogate endpoint validation using mediation analysis and meta-analytic data - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36398615/
With the ongoing development of treatments and the resulting increase in survival in oncology, clinical trials based on endpoints such as overall survival may require long follow-up periods to observe...
Conclusions: ”In this article, we propose an approach to validate surrogates when both the surrogate and final endpoints are censored event times. This approach is developed for meta-analytic data and uses a mediation analysis to decompose the total effect of the treatment on the final endpoint as a direct effect and an indirect effect through...
New β-carboline derivatives containing imidazolium as potential VEGFR2 inhibitors: synthesis, X-ray structure, antiproliferative evaluations, and molecular modeling
Source : https://pubs.rsc.org/en/content/articlelanding/2022/MD/D2MD00065B
A series of new β-carboline derivatives containing an imidazolium moiety were designed and synthesized via the reaction of β-carboline-1-carboxaldehydes, acetyl chloride, primary amine, and formaldehyde. The antitumor activity of the...
Relevance: A series of new β-carboline derivatives containing an imidazolium moiety were designed and synthesized via the reaction of β-carboline-1-carboxaldehydes, acetyl chloride, primary amine, and formaldehyde. The antitumor activity of the synthesized compounds was examined against lung carcinoma (A549), gastric carcinoma (BGC-823),...
Perspectives of laparoscopic surgery for gastric cancer
Source : https://article.cjcrcn.org/en/article/doi/10.21147/j.issn.1000-9604.2022.05.12?viewType=HTML
Gastrectomy is the main treatment option for gastric cancer patients. Laparoscopic approach has become popular as an alternative to open method during the last decades, and clinical trials have revealed...
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Conclusions and future perspectives: Laparoscopic subtotal gastrectomy has been established as a standard procedure alternative to open surgery. For patients with advanced proximal gastric cancer, laparoscopic total gastrectomy is under active research and is expected to yield promising short- and long-term outcomes. The indication of...
Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36367659/
Helicobacter pylori (H. pylori) is a common pathogen that infects more than half of the world's population. Its infection can not only lead to a variety of gastrointestinal diseases, such...
Relevance:In this article, we provide a systematic review on the role of exosomal miRNAs in H. pylori-associated GC.