Safety and Efficacy of Treatment with/without Ramucirumab in Advanced or Metastatic Cancer: A Meta-Analysis of 11 Global, Double-Blind, Phase 3 Randomized Controlled Trials
Source : https://www.hindawi.com/journals/jo/2022/2476469/
Ramucirumab, as a vascular endothelial growth factor receptor-2 inhibitor, was first approved in 2014 for treated advanced or metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. This study deeply analyzed the efficacy and...
Conclusions: Ramucirumab, as a vascular endothelial growth factor receptor-2 inhibitor, was first approved in 2014 for treated advanced or metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. This study deeply analyzed the efficacy and safety of advanced or metastatic cancer treated with ramucirumab, which included 11 global,...
HSPA6, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36458368/
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Conclusions: HSPA6 promotes GC proliferation by the Hippo pathway, as a novel prognostic biomarker and potential therapeutic target.
Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression
Source : https://www.sciencedirect.com/science/article/abs/pii/S0955286322002947?via=ihub
Available online 23 November 2022, 109226 Author links open overlay panel Qi Zhang 1 2 Envelope ↑ Wanshuang Cao 1 Envelope ↑ Chenying Yang 1 Envelope ↑ Lixia Hong Envelope...
Conclusions: Our findings provide novel insights as isothiocyanates could interfere with the successful application of immunotherapy in gastric cancer.
Data collection framework for electronic medical record-based real-world data to evaluate the effectiveness and safety of cancer drugs: a nationwide real-world study of the Korean Cancer Study Group - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36339930/
This real-world study provides a framework that ensures relevance and reliability of EMR-based RWD for evaluating the effectiveness and safety of cancer drugs.
Conclusions: This real-world study provides a framework that ensures relevance and reliability of EMR-based RWD for evaluating the effectiveness and safety of cancer drugs."
Multiple-dose up-titration study to evaluate the pharmacokinetics, safety and antitumor activity of apatinib in advanced gastric adenocarcinoma
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.876899/full
Background and purposeThe objective of this study was to investigate the pharmacokinetics, safety, and antitumor activity of apatinib, a vascular endothelial growth factor receptor 2 inhibitor, in advanced gastric adenocarcinoma...
Conclusions: Conclusions: Apatinib dose titration based on toxicity could be used in clinical practice to provide optimal dosage for individual patients.