Delayed pharyngocutaneous fistula caused by molecular targeted therapy: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36271412/
Although the incidence of late drug-induced anastomotic leakage is very low, when it occurs, it makes oral intake impossible for an extended period and interferes with the appropriate cancer treatment....
Conclusions: Although the incidence of late drug-induced anastomotic leakage is very low, when it occurs, it makes oral intake impossible for an extended period and interferes with the appropriate cancer treatment. In this report, we demonstrate the details of these two patients with such a rare complication, which may help accumulate...
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36469496/
Studies have revealed the contribution of ATP-G protein-coupled P2Y2 receptor (P2RY2) in tumor progression, but the role of P2RY2 in regulating the progression of gastric cancer (GC) and related molecular...
Conclusions: Studies have revealed the contribution of ATP-G protein-coupled P2Y2 receptor (P2RY2) in tumor progression, but the role of P2RY2 in regulating the progression of gastric cancer (GC) and related molecular mechanisms are relatively lacking. Therefore, this study investigates the effects of P2RY2 on the proliferation and migration of...
The prognostic impact of tumor-infiltrating B lymphocytes in patients with solid malignancies: a systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36481308/
This study reviewed the prognostic effect of tumor-infiltrating B lymphocytes (TIBLs) on solid malignancies, to determine the potential role of TIBLs in predicting cancer patient's prognosis and their response to...
Conclusions: We concluded that TIBLs play a favorable prognostic role among the common solid malignancie, providing theoretical evidence for further prognosis prediction for solid tumors.
Treatment efficacy of ramucirumab-containing chemotherapy in patients with alpha-fetoprotein producing gastric cancer - International Journal of Clinical Oncology
Source : https://link.springer.com/article/10.1007/s10147-022-02263-0
Background Alpha-Fetoprotein Producing Gastric Cancer (AFPGC) is an aggressive subgroup of gastric cancer. Recently ramucirumab has shown survival benefits in hepatocellular carcinoma, but only in those with higher Alpha-Fetoprotein (AFP)...
Conclusions: The meta-analysis showed that standard regimens combined with ramucirumab resulted in more beneficial PFS and OS outcomes in advanced NSCLC, HCC, gastric cancer, or GEJ adenocarcinoma. The importance of the results for clinical practice was that the incidence of hypertension, proteinuria, bleeding, liver injury/failure, VTE, and GI...
Report of two patients in whom comparisons of the somatic mutation profile were useful for the diagnosis of metastatic tumors - Surgical Case Reports
Source : https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-022-01566-8
Background When a patient has multiple tumors in different organs, it is very important to identify whether the tumors are multiple cancers or metastasis from one tumor in order to...
Conclusions: " We reported two patients with multiple tumors in which a somatic mutation comparison using NGS was useful for the diagnosis of a metastatic tumor."