Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline
Source : https://ascopubs.org/doi/10.1200/JCO.22.02331
PURPOSE To develop recommendations involving targeted therapies for patients with advanced gastroesophageal cancer. METHODS The American Society of Clinical Oncology convened an Expert Panel to conduct a systematic review of...
Conclusions: This guideline incorporates the most recent evidence from RCTs of immunotherapy and targeted therapy for patients with advanced gastroesophageal cancer. These new studies will help to fill a need for therapy options in this population, which historically has had few effective treatment options.
WZ35 inhibits gastric cancer cell metastasis by depleting glutathione to promote cellular metabolic remodeling
Source : https://www.sciencedirect.com/science/article/abs/pii/S0304383522005316?via=ihub
This study aimed at elucidating the crosstalk between redox reaction and metabolic remodeling through uncovering the mechanism underlying WZ35-mediated reactive oxygen species (ROS) production and regulation of amino acid metabolism...
Conclusions: Our study identified WZ35 as a novel GSH depletion agent and a previously undiscovered GSH depletion loop mechanism in GC cell metastasis.
Risk factor analysis for duodenal margin positivity following gastrectomy for resectable gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36575564/
Locally advanced tumors and pyloroantral tumors are associated with an increased risk of duodenal margin positivity after gastrectomy for carcinoma stomach and may benefit from intraoperative frozen section analysis as...
Conclusions: Locally advanced tumors and pyloroantral tumors are associated with an increased risk of duodenal margin positivity after gastrectomy for carcinoma stomach and may benefit from intraoperative frozen section analysis as survival is negatively affected by positive RM. Patients with high-risk features like extensive nodal and...
Systemic Therapy in Advanced Hepatocellular Carcinoma: Patient Selecti | JHC
Primary liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma, is the sixth-most common cancer and the third-leading cause of cancer-related death worldwide, with >900,000 newly diagnosed cases and approximately...
Conclusions: As immunotherapy makes its way into the therapeutic landscape of HCC, other novel targeted therapies, such as lenvatinib, cabozantinib, ramucirumab, and regorafenib, have also been approved by regulatory authorities for treatment of advanced, unresectable HCC. This review article focuses on the first-line systemic treatment options...
LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis
Source : https://www.tandfonline.com/doi/abs/10.1080/1120009X.2022.2157618?journalCode=yjoc20
Abstract Gastric cancer (GC) is one of the most malignant tumors with high incidence and poor prognosis. Currently, the combination of surgery with chemo- or radiotherapy is widely applied therapeutic...
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Conclusions: Restoration of miR-216b-5p in SNHG1-overexpressing MKN-45 TXR cells successfully overrode the SNHG1-promoted Taxol resistance through targeting the HK2-glycolysis axis. This study uncovered new biological roles and molecular mechanisms of the lncRNA-SNHG1-mediated Taxol resistance of gastric cancer, suggesting targeting the...