Current progress and challenges of immunotherapy in gastric cancer: A focus on CAR-T cells therapeutic approach
Source : https://www.sciencedirect.com/science/article/abs/pii/S0024320523000930?via=ihub
Available online 30 January 2023, 121459 Author links open overlay panel Mahshad Entezam a b 1 , Mohammad-Javad Sanaei c 1 , Yousef Mirzaei d , Ali Hussein Mer e...
Conclusions: Despite the challenges of CAR therapy in solid tumors, CAR therapy targets various GC cells targets; among them, intercellular adhesion molecule (ICAM)-1 CAR-T cell and CLDN18.2 CAR-T cell have shown promising results. Although responses to all these treatments are encouraging and in some cases, durable, these successes are not...
Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36555740/
Cancer accounts for one in seven deaths worldwide and is the second leading cause of death in the United States, after heart disease. One of the standard cancer treatments is...
Conclusions: This review highlights the different critical mechanisms by which fucoxanthin inhibits diverse cancer types, such as breast, prostate, gastric, lung, and bladder development and progression. Moreover, this article reviews the existing literature and provides critical supportive evidence for fucoxanthin's possible therapeutic use in...
Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues
Source : https://www.sciencedirect.com/science/article/pii/S2001037022006079?via=ihub
We constructed a multi-cancer EC atlas and revealed the differences between tumor ECs and normal tissue ECs across multiple cancer types via integrated analysis of single cell and bulk RNA-seq...
Conclusions: We demonstrate that tip-like ECs are the main differential EC subcluster between tumors and normal tissues. Tip-like ECs may promote tumor progression through promoting angiogenesis while inhibiting anti-tumor immune responses. PSMA was a specific marker for tip-like ECs, which could be used as a potential target for the...
Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36484282/
Proton pump inhibitors (PPIs) are potent inhibitors of gastric acid secretion, used as first-line agents in treating peptic ulcers. However, we have previously reported that PPIs may diminish the therapeutic...
Conclusions: Vonoprazan does not affect VEGF expression in cancer cells, which suggests that vonoprazan might be an alternative to PPIs, with no interference with the therapeutic effects of anti-VEGF cancer chemotherapy.
Effects of Tegafur, Gimeracil and Oteracil Potassium Capsules combined with Calf Spleen Extractive Injection on serum VEGF and MMP-9 in patients with advanced gastric cancer
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730097/
Clinically, gastric cancer is a malignant tumor of the digestive system with high incidence, and if the cancerous tissue has invaded the serosal and the muscle layers, it is defined...
Conclusions: CSEI combined with Oxaliplatin and TGOPC could further improve the clinical efficacy and survival of patients, reduce the incidence of adverse reactions, and exerts significant anti-tumor effects, so this combined treatment is worthy of promotion.