Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer
Source : https://www.frontiersin.org/articles/10.3389/fgene.2023.1128088/full
This study systematically and comprehensively analyzed the characteristics of matrix metalloproteinases (MMPs) in gastric cancer (GC) and revealed the relationship between MMPs and prognoses, clinicopathological features, tumor microenvironment, gene mutations,...
Conclusions/Relevance: Overall, MMP could be involved in the tumor microenvironment (TME), clinical features, and prognosis of GC. An in-depth study of MMP patterns can better understand the indispensable role of MMP in the development of GC and reasonably assess the survival prognosis, clinicopathological features, and drug efficacy of...
Laparoscopic-assisted robotic distal gastrectomy for gastric cancer by Billroth II reconstruction - Langenbeck's Archives of Surgery
Source : https://link.springer.com/article/10.1007/s00423-023-02895-4
Background There are several reconstructions in distal gastrectomy for gastric cancer, and there is no clear definition regarding the method selection. The optimal reconstruction is likely to vary according to...
Conclusion: We successfully arranged Billroth II reconstruction for robotic distal gastrectomy with fewer operative and postoperative complications. Laparoscopic-assisted robotic gastrectomy using extracorporeally inserted devices, and continuous suturing using a barbed suture will reduce the time and cost of robotic gastrectomy.
Spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37145865/
Intestinal-type gastric cancer arises in a field of precancerous metaplastic lineages. Two types of metaplastic glands are found in the stomachs of humans with the characteristics of pyloric metaplasia or...
Conclusions/Relevance: While this investigation clearly demonstrates a connection of SPEM cell lineages to the development of cancer, these studies do not address whether other intestinalized cell lineages within incomplete intestinal metaplasia glands also can serve as de novo sources of dysplastic stem cells. Certainly, normal isthmal...
Survival Benefits of Laparoscopic Gastrectomy in Elderly Patients With Gastric Cancer: Focusing on Preoperative Nutritional and Inflammatory Status
Source : https://ar.iiarjournals.org/content/43/5/2055
Background/Aim: Laparoscopic gastrectomy (LG) may have greater clinical benefits as a less invasive surgery for elderly patients with gastric cancer (GC). Therefore, we aimed to evaluate the survival benefit of...
Conclusion: LG might offer greater survival benefits than OG in frail patients such as those with high NLR.
Assessment of the efficacy and safety of carbon nanoparticles-guided lymph node dissection in gastric cancer surgery: a systematic review and meta-analysis - International Journal of Clinical Oncology
Source : https://link.springer.com/article/10.1007/s10147-023-02333-x
Background To investigate the efficacy and safety of lymph nodes (LNs) dissection guided by carbon nanoparticles (CNs) in gastric cancer (GC) surgery. Materials and methods We searched electronic databases such...
Conclusion: CNs-guided gastrectomy is safe and effective, and can increase the efficiency of LN dissection without increasing the risk of surgery.