Monocyte-to-lymphocyte ratio as a determinant of survival... : Medicine
ction were enrolled in this study. Cox regression analysis was used to determine the independent variables for overall survival (OS) and disease-free survival (DFS). The established models were validated internally....
Conclusion: Age, TNM stage, PNI, ALB, and MLR were significant determinants of both OS and DFS, and constituted the full model. The full model was suggested to outperform TNM stage in predicting both OS and DFS. Therefore, our findings may help surgeons better differentiate patients with poor survival before gastrectomy. However, because MLR...
Acacetin exerts antitumor effects on gastric cancer by targeting EGFR
Source : https://www.frontiersin.org/articles/10.3389/fphar.2023.1121643/full
Background: Gastric cancer (GC) is a common malignant tumor with a poor prognosis. Combination treatments may prolong the survival of patients with GC.
Conclusion: Our findings highlight EGFR as one of the direct targets of acacetin in GC cells. Acacetin inhibited the phosphatase activity of EGFR in vitro and in vivo, which played a role in the antitumor effects of acacetin. These studies provide new evidence for the use of acacetin as a potential reagent for the treatment of GC.
Successful management of multiple liver metastasis from gastric cancer with second conversion surgery: A case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37216732/
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Discussion: A second conversion surgery with stageIV gastric cancer after third-line chemotherapy with nivolumab is rare. Multiple hepatectomy as conversion surgery may be an option to control liver metastases.
Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37196541/
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Summary: This study provides a comprehensive review and summary of the physico-chemical properties, anticancer effects and molecular mechanisms, toxicity, pharmacokinetics, and current challenges and prospects of celastrol, with the aim of providing a theoretical basis for the development and clinical application of celastrol.
Effects of prior therapies on outcomes with trifluridine/tipiracil in patients with metastatic gastric/gastroesophageal junction cancer in a randomized phase III trial (TAGS) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37213030/
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Conclusions: In TAGS, third- or later-line trifluridine/tipiracil treatment demonstrated overall and progression-free survival and functioning benefits versus placebo and a consistent safety profile in patients with metastatic gastric/gastroesophageal junction cancer, regardless of prior treatment type.