Cortactin contributes to the tumorigenesis of gastric cancer by activating ERK/MMP pathway - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37539204/
Gastric cancer is a malignant tumor with high mortality and high incidence. This study aims to explore the function and molecular mechanism of Cortactin on gastric cancer progression in vitro...
Relevance: This study aims to explore the function and molecular mechanism of Cortactin on gastric cancer progression in vitro and in vivo. A bioinformatics analysis from TCGA displayed that Cortactin was highly expressed in gastric cancer samples, and patients with a high Cortactin level had a worse survival rate.
Real-World Treatment Patterns and Economic Burden Following First-Line Trastuzumab in Patients with Metastatic Gastric Cancer in the USA - Drugs - Real World Outcomes
Source : https://link.springer.com/article/10.1007/s40801-023-00378-y
Background Trastuzumab in combination with chemotherapy is the standard first-line (1L) treatment for HER2+ metastatic gastric cancer (mGC) in the USA. Objective This study characterizes the real-world treatment patterns, healthcare...
Conclusions: The short duration of 2L treatment observed in this study is consistent with a lack of effective treatments post-1L trastuzumab prior to 2020. Re-use of trastuzumab treatment was common despite its limited efficacy and high treatment cost. The findings highlight the unmet medical needs and substantial burden faced by patients with HER2 +mGC previously treated with trastuzumab.
Effect of massive ascites on ramucirumab pharmacokinetics in patients with gastrointestinal cancers: a population pharmacokinetic analysis - Cancer Chemotherapy and Pharmacology
Source : https://link.springer.com/article/10.1007/s00280-023-04568-x
Purpose Considerable amounts of injected immunoglobulin G-based therapeutic monoclonal antibodies, such as ramucirumab, are distributed into ascites. This study aimed to examine the effect of massive ascites on ramucirumab pharmacokinetics...
Conclusion: In the present study, the presence of massive ascites affected the pharmacokinetics of ramucirumab in patients with gastrointestinal cancers. Our results suggest that dose optimization of ramucirumab may be necessary in patients with massive ascites due to higher ramucirumab clearance.
Comparison of the efficacy and safety of first-line treatments for of advanced EGFR mutation-positive non-small-cell lung cancer in Asian populations: a systematic review and network meta-analysis
Source : https://www.frontiersin.org/articles/10.3389/fphar.2023.1212313/full
Background: According to the 2023 guidelines for treating non-small-cell lung cancer (NSCLC), first-line treatment and recently developed agents for the treatment of epidermal growth factor (EGFR) mutation-positive locally advanced or...
Conclusion: Based on these analyses of survival benefits, tumor burden response, and safety, furmonertinib (Fur), Osi, and aumolertinib (Aum) may represent the best treatment regimen options for Asian patients, significantly prolonging survival (as measured by median PFS/OS), eliciting a greater tumor burden response, and exposing patients to a lower risk of adverse events. Although Erl + Bev and Erl + Ram are associated with the best survival benefits in terms of PFS, further clinical studies are still needed to identify ways to reduce the risk of adverse events.
A Case of Pathologically Complete Response After Nivolumab Combined with Chemotherapy in a Gastric Cancer Patient with Virchow's Lymph Node Metastasis
Describing a rare case of initially unresectable gastric cancer treated with nivolumab combined chemotherapy, achieving a pathologically complete response
Conclusion: The present study reports a rare case of initially unresectable gastric cancer with Virchow’s LNM showing a pathologically complete response to pre-operative chemotherapy combined with ICI. A treatment strategy that evaluates distant metastasis, aiding in the decision on whether to perform curative conversion surgery, may be effective for unresectable gastric cancer.
The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma - Journal of Experimental & Clinical Cancer Research
Source : https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02615-2
Background Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis. However, monotherapy of CDK4/6 inhibitors has shown limited antitumor effects...
Conclusion: This study thus proposes a candidate combination therapy of ABE and JQ1 to improve the therapeutic efficacy and worth further investigation in clinical trials for GC.
p16 methylation is a potential predictive marker for abemaciclib sensitivity in gastric cancer
Source : https://www.sciencedirect.com/science/article/abs/pii/S0006295220305566?via=ihub
Cell cycle control is often disrupted in gastric cancer (GC), making it an attractive therapeutic target. Abemaciclib is a specific CDK4/6 inhibitor t...
Conclusions/Relevance: Collectively, these data provide a foundation for clinical trials to assess the therapeutic efficacy of abemaciclib in GC and suggest that p16 methylation could be used as a predictive marker to identify patients with GC who may benefit from abemaciclib-based therapies.
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/30344100/
Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we...
Relevance: Overall, this new GCO biobank, with linked genomic data, provides a useful resource for studying both cancer cell biology and precision cancer therapy.
Characteristic analysis of early gastric cancer after Helicobacter pylori eradication: a multicenter retrospective propensity score-matched study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37450336/
Our multicenter study revealed that EGC after H. pylori eradication was characterized by long-term PPI use, moderate mucosal atrophy, mucosal map-like redness, the mild activity of gastric mucosa, a higher...
Conclusion: Our multicenter study revealed that EGC after H. pylori eradication was characterized by long-term PPI use, moderate mucosal atrophy, mucosal map-like redness, the mild activity of gastric mucosa, a higher proportion of HGIN cases, and lower levels of Ki-67.
Serum Interleukin 6 Level is Associated With Overall... : Annals of Surgery
dy, we evaluated the relationship of circulating serum cytokine levels with overall survival (OS) and pathologic tumor regression grade (TRG) in G+GEJ patients. Methods: We queried the UT Southwestern gastric...
Conclusion: Pre-treatment serum level of IL-6 is a promising prognostic biomarker for G+GEJ patients. Comparing pre- and post-neoadjuvant IL-6 levels may predict pathologic response to neoadjuvant therapy.