Bortezomib enhances the anti-cancer effect of the novel Bruton's tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34508613/
1 Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer,...
Severe infections in patients with lymphoproliferative diseases treated with new targeted drugs: A multicentric real-world study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34558211/
A high proportion of patients presented severe infections during follow-up, with non-negligible attributable mortality, but infection incidence is not superior to the one observed during the chemotherapy era. In selected...
Slow progression of a MCL 10 years ago who developed orbital relapse 3 years ago resolved with radiation. Has had progressive pulmonary nodules which were noted on presentation at diagnosis and resolved and have slowly recurred. initial treatment with Nordic regimen. neuropathy. Declined SCT as consolidation. He is 63. I inclined to observe...
Integrated safety analysis of umbralisib, a dual PI3Kδ/CK1ε inhibitor, in relapsed/refractory lymphoid malignancies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34547767/
Phosphoinositide 3-kinase-delta (PI3Kδ) inhibitors are active in lymphoid malignancies, though associated toxicities can limit their use. Umbralisib is a dual inhibitor of PI3Kδ and casein kinase-1ε (CK1ε). This study analyzed...
DNA methylation-based classification of small B-cell lymphomas: a proof-of-principle study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34562613/
While most small B-cell lymphomas (SBCLs) can be diagnosed using routine methods, challenges exist. For example, marginal zone lymphomas (MZLs) can be difficult to rule-in, in large part because there...