Phase I/Ib study of the efficacy and safety of buparlisib and ibrutinib therapy in MCL, FL, and DLBCL with serial cell-free DNA monitoring - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34615723/

2021 Oct 6;clincanres.CCR-21-2183-A.2021. doi: 10.1158/1078-0432.CCR-21-2183. Online ahead of print. 1 Medicine, Memorial Sloan Kettering Cancer Center. 2 Radiology, Memorial Sloan Kettering Cancer Center. 3 Epidemiology and Biostatistics, Memorial Sloan Kettering...

Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34625994/

Combinations of targeted agents are now being investigated to create efficient, potentially curative therapies of CLL with fixed duration. One of the most relevant questions currently addressed in clinical trials...

Chronic lymphocytic leukemia with t(6;14) (p21;q32) CCND3-IGH: CCND3 rearrangement does not necessarily define a cyclin D1-negative mantle cell lymphoma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34596253/

doi: 10.1002/hon.2930. Online ahead of print. 1 Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China. 2 Department of Pathology, Duke...

Discovery of novel covalent BTK inhibitors with reduced CYP2C8 inhibitory activity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34582626/

Bruton's tyrosine kinase (BTK) is a member of the Tec kinase family that is expressed in cells of hematopoietic lineage. Evidence has shown that inhibition of BTK has clinical benefit...

The role of BTK in the immune system and disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34534359/

Bruton's Tyrosine kinase (BTK) is a TEC kinase with a multifaceted role in B-cell biology and function, highlighted by its position as a critical component of the B-cell receptor signalling...